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Role of clomiphene citrate in infertile men with oligozoospermia

Clomiphene citrate: Role in infertile men with oligozoospermia

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2023/11/059791
Enrollment
200
Registered
2023-11-14
Start date
Unknown
Completion date
Unknown
Last updated
2023-12-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: N461- Oligospermia

Interventions

Intervention1: clomiphene citrate: Clomiphene citrate given orally 25mg, once daily for 3 months. Semen analysis and serum testosterone levels done before starting the drug and after taking drug for 3

Sponsors

Dr Tejas Gundewar
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Subfertile men with abnormal semen parameters. 2. Couples where female factor infertility has been ruled out. 3. Serum Testosterone level <300ng/dl. 4. Serum FSH/LH between 1.2 -10 IU/L

Exclusion criteria

Exclusion criteria: EXCLUSION CRITERIA: 1. Baseline Serum Testosterone > 300 ng/dL. 2. Azoospermia. 3. Men with Hypergonadotropic hypogonadism (FSH >10IU/L, LH >10IU/L). 4. Men with Hypogonadotropic Hypogonadism (FSH 1.2 IU/L, LH<1.2IU/L). 5. Not willing to participate. 6. Varicocele has to be ruled out.

Design outcomes

Primary

MeasureTime frame
To study the effect of clomiphene citrate in improving sperm count in infertile men with oligospermia.Timepoint: Baseline and 12 weeks—

Secondary

MeasureTime frame
To study the pregnancy rates after treatment with clomiphene citrate. 2. To study the effect of clomiphene citrate on progressive motility of sperms. 3. To study the effect of clomiphene citrate on sperm morphology. 4. To study the effect of clomiphene citrate on semen volume. 5. To study the effect of clomiphene citrate on testicular size. 6. To study the effect of clomiphene citrate on serum total testosterone levels.Timepoint: Baseline and 12 weeks—

Countries

India

Contacts

Public ContactTejas Gundewar

Chief male and female infertility consultant, Ruby Hall Clinic, 40 -sassoon road, Pune

tejasgundewar87@gmail.com9970054337

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026