Health Condition 1: P073- Preterm [premature] newborn [other]
Conditions
Interventions
Intervention1: Intermittent phototherapy: Phototherapy will be administered cyclical with 3 hours ON time followed by 3 Hours OFF time.
Control Intervention1: Continuous phototherapy: Phototherapy wil
Sponsors
Surya Childrens Medicare Pvt. Ltd.
Seth GS Medical College and KEM Hospital
Eligibility
Inclusion criteria
Inclusion criteria: Preterm infant born at Gestational age 29+0 to 33+6 weeks and indicated for phototherapy in the first 14 days of postnatal life.
Exclusion criteria
Exclusion criteria: 1.Serious congenital anomaly, 2.Infant with Rh or ABO isoimmunisation. (Direct coombs test Positive) 3.Infant with G6PD deficiency. 4.Infants requiring phototherapy after 14 days of postnatal age. 5.Out born infant with phototherapy initiated prior to admission. 6.Infant birth weight 7.Severe hyperbilirubinemia at first screening (TSB within 1-1.5 mg/dl of the exchange transfusion cut-off for gestational age.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Rate of change (mg/dl/day) of total serum bilirubin level.Timepoint: Day 1-14. | — |
Secondary
| Measure | Time frame |
|---|---|
| Abnormal BERATimepoint: at 3-4 months of corrected age;All-cause MortalityTimepoint: till discharge;Conjugated hyperbilirubinemiaTimepoint: till discharge;Duration of phototherapy (Hours)Timepoint: Day 1-14.;Feed interruption hoursTimepoint: Day 1-14.;Need for exchange transfusion.Timepoint: Day 1-14.;Need for incremental phototherapy.Timepoint: Day 1-14.;Need for intensive phototherapy.Timepoint: Day 1-14.;Neurodevelopmental impairment at 18 to 24 months of age.Timepoint: 18-24 months of age;Peak TSB (mg/dl)Timepoint: Day 1-14.;Rates of phototherapy re-initiationTimepoint: Day 1-14.;Rates of Rebound hyperbilirubinemia.Timepoint: Day 1-14.;Time to reach full enteral feeds. (150ml/kg/day)Timepoint: Day 1-14. | — |
Countries
India
Contacts
Public ContactNikhil Thumar
Surya Childrens Medicare Pvt. Ltd.
Outcome results
None listed