A study to compare the effect of dexmedetomidine and lignocaine on pain control after cardiac surgery

Comparison of intravenous dexmedetomidine and lignocaine in combination with parasternal intercostal block on postoperative analgesia in adult patients undergoing cardiac surgery- A prospective randomized study - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/11/059673

Enrollment

Registered

2023-11-08

Start date

Unknown

Completion date

Unknown

Last updated

2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Intravenous Dexmedetomidine along with parasternal intercostal block: Group PD - Parasternal block + 0.5 mcg/kg dexmedetomidine loading dose over 15 min followed by 0.4 mcg/kg/hr. Paras

Eligibility

Inclusion criteria

Inclusion criteria: 1.Age 18-65 years 2.All consenting patient with elective cardiac surgeries through median sternotomy using cardiopulmonary bypass.

Exclusion criteria

Exclusion criteria: 1.Patients with preoperative cognitive impairment. 2.Patients on mechanical ventilation support or inotropes or intra-aortic balloon pulsation preoperatively 3.Patients with a history of previous cardiac surgery 4.Patients with LVEF 5.Patients allergic to study drugs and addicted to narcotics 6.Patient with chronic liver and renal disease. 7.Patient with heart rate

Design outcomes

Primary

Measure	Time frame
To assess and compare dexmedetomidine and lignocaine infusions in combination with parasternal intercostal block on postoperative analgesic(Fentanyl and Tramadol) requirements in patients undergoing cardiac surgery.Timepoint: 24 hours post operatively	—

Secondary

Measure	Time frame
2. To compare the postoperative Visual Analogue Scale (VAS) pain scores in patients undergoing cardiac surgery after dexmedetomidine and lignocaine infusions in combination with parasternal intercostal block.Timepoint: VAS score at first spontaneous eye opening and after that every 4 hourly (12,16,20,24 hr) postoperatively.;3. To compare the intraoperative and postoperative hemodynamic stability in patients undergoing cardiac surgery after dexmedetomidine and lignocaine infusions in combination with parasternal intercostal block.Timepoint: Four hourly after shifting to ICU (P0, P4,P8, P12,P16, P20,P24);1. To compare the duration of postoperative mechanical ventilation in patients undergoing cardiac surgery after dexmedetomidine and lignocaine infusions in combination with parasternal intercostal blockTimepoint: 12 hours postoperatively	—

Measure

Time frame

2. To compare the postoperative Visual Analogue Scale (VAS) pain scores in patients undergoing cardiac surgery after dexmedetomidine and lignocaine infusions in combination with parasternal intercostal block.Timepoint: VAS score at first spontaneous eye opening and after that every 4 hourly (12,16,20,24 hr) postoperatively.;3. To compare the intraoperative and postoperative hemodynamic stability in patients undergoing cardiac surgery after dexmedetomidine and lignocaine infusions in combination with parasternal intercostal block.Timepoint: Four hourly after shifting to ICU (P0, P4,P8, P12,P16, P20,P24);1. To compare the duration of postoperative mechanical ventilation in patients undergoing cardiac surgery after dexmedetomidine and lignocaine infusions in combination with parasternal intercostal blockTimepoint: 12 hours postoperatively

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Countries

India

Contacts

Public ContactDr S R A N Bhushanam Padala

All India Institute of Medical Science, Bhopal

padala72@gmail.com7893562302

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Mar 14, 2026