Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: Radiofrequency ablation of splanchnic nerves: Radiofrequency ablation of splanchnic nerves at T11 level.
Agent and sequence:
1)2mL of local anaesthetic each side.(2% Lignocaine + 0.25%
Sponsors
All India Institute of Medical Sciences, Raipur, Cggattisgarh
Eligibility
Inclusion criteria
Inclusion criteria: 1.Cancer of Pancreas, gallbladder, Liver, Stomach, Intestine up to splenic flexure of colon, lower one third of oesophagus. (Upper GI Malignancy) 2. Cancer pain not responding to morphine and other opioids like buprenorphine, fentanyl patch 3. Coagulation parameters within normal limits 4. Life expectancy more than 3 months
Exclusion criteria
Exclusion criteria: 1. Uncontrolled international normalized ratio (INR) 2. Systemic or local infection 3. Expected survival less than 3 months, an 4. Eastern Cooperative Oncology Group (ECOG) score less than 3 5. Presence of a medical or psychiatric illness that would preclude informed consent or follow-up 6. Patient mentally retarded, not following verbal commands during radiofrequency ablation when checking sensory and motor testing
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare the pain relief after bilateral thoracic splanchnic nerve radiofrequency ablation at T11 with chemical neurolysis with absolute alcohol at T11.Timepoint: to assess at 7,14,21,28 days | — |
Secondary
| Measure | Time frame |
|---|---|
| To compare the incidence of side effects such as diarrhoea, hypotension and reduction in oral morphine consumption, improvement in quality of life between two techniques.Timepoint: to assess at 7,14,21,28 days | — |
Countries
India
Contacts
Public ContactDr Rampal Singh
All India Institute Of Medical Sciences, Raipur, Chhattisgarh
Outcome results
None listed