A study to see the incidense in pain reduction after amputation of leg below the knee joint by injecting blood component(platelet rich plasma) in nerve near the knee joint

Ultrasound guided perineural platelet rich plasma injection to prevent post amputation pain in patients undergoing below knee amputation: a randomised controlled trial - NIL

Status

Active, not recruiting

Phases

Phase 1Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/11/059484

Enrollment

110

Registered

2023-11-02

Start date

Unknown

Completion date

Unknown

Last updated

2023-11-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M968- Other intraoperative and postprocedural complications and disorders of musculoskeletal system, not elsewhere classified

Interventions

Intervention1: Dr.Ashwani Thakur: Perineural administration of platelet rich plasma around the sciatic nerve in popliteal fossa for studying the effect on post below knee post amputation pain after 3

Eligibility

Inclusion criteria

Inclusion criteria: Patients between age group 18 years to 65 years undergoing unilateral below-knee amputation

Exclusion criteria

Exclusion criteria: 1.Patients with thrombocytopenia (platelet count less than 1 lac/mm3) or coagulopathy (INR >1.5) 2.Peripheral limb ischemia, 3.Pregnant patient, 4.Patient with head injury 5.Known case of any previous allergy to PRP 6.Haemoglobin concentration less than 8 gm/dl 7.Relatives unwilling to give consent for participation in the study

Design outcomes

Primary

Measure	Time frame
Pain status at 3 months following discharge using the Brief Pain inventory (BPI)Timepoint: 2 hrs, 6 hrs, 12 hrs, 24 hrs, 15 days and 3 months	—

Secondary

Measure	Time frame
Total morphine consumption in 24 hrs Pain scores at 2 hrs, 6 hrs, 12 hrs and 24 hrs Incidence of phantom pain, stump pain and phantom limb sensation at 15 days, one-month and 3 months post operatively Quality of life at 3 months using SF36 score Pain disability index score at 3 months Anxiety depression using Hospital anxiety depression score HADSTimepoint: 2 hrs, 6 hrs, 12 hrs, 24 hrs, 15 days and 3 months	—

Measure

Time frame

Total morphine consumption in 24 hrs Pain scores at 2 hrs, 6 hrs, 12 hrs and 24 hrs Incidence of phantom pain, stump pain and phantom limb sensation at 15 days, one-month and 3 months post operatively Quality of life at 3 months using SF36 score Pain disability index score at 3 months Anxiety depression using Hospital anxiety depression score HADSTimepoint: 2 hrs, 6 hrs, 12 hrs, 24 hrs, 15 days and 3 months

—

Countries

India

Contacts

Public ContactAshwani thakur

Postgraduate Institute of Medical Education and Research, Chandigarh

jeet1516@gmail.com8847288105

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026