A clinical trial to study the effect of a biological agent(injectable Platelet rich fibrin)on the rate of tooth movement and the pain associated with it.

Evaluation of rate of Canine Retraction and expression of pain marker in GCF after the administration of i-PRF - NIL

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/11/059480

Enrollment

Registered

2023-11-02

Start date

Unknown

Completion date

Unknown

Last updated

2023-11-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: injectable-Platelet rich Fibrin: 0.5 ml on the test side at the appointment retraction is started. Retraction continued for 3 month. Control Intervention1: Not applicable: Control side

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients with no or minimal crowding, proclined teeth and high tooth material, arch length discrepancy in both maxillary and mandibular arches that were indicated for maxillary first premolar extraction and bilateral maxillary canine distalization. 2. Age group of 12-25 years. 3. Clinically healthy patients with no systemic illness. 4. Patients with no previous history of Orthodontic treatment. 5. Patients with proper Oral hygiene Control.

Exclusion criteria

Exclusion criteria: 1. Periodontal tissues with generalized probing depth >3 mm 2. Periodontal bone loss according to their radiographs. 3. Trauma from Occlusion 4. History of local and systemic antibiotics and anti-inflammatory drugs administration in last three months of starting the study. 5. Smokers 6. History of systemic illness

Design outcomes

Primary

Measure	Time frame
To investigate the effect of injectable - platelet rich fibrin administration on the rate of canine retraction.Timepoint: Baseline and 3 months	—

Secondary

Measure	Time frame
? To compare and correlate the pain marker (substance P) in Gingival Crevicular Fluid, between control and experimental side.Timepoint: Before, 24 hours, 5 days, 15 days, 3 months	—

Countries

India

Contacts

Public ContactHuma Azad

Dr. Ziauddin Ahmad Dental College, AMU, Aligarh

dr.vermask@rediffmail.com9358254765

Outcome results