Health Condition 1: G998- Other specified disorders of nervous system in diseases classified elsewhere
Conditions
Sponsors
NIMHANS
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patients aged 18 to 65 years of age 2. Anterior cerebral circulation aneurysm with subarachnoid hemorrhage 3. WFNS grade 1-3 4. Presentation within 3 days of ictus 5. Scheduled to undergo microsurgical clipping of aneurysm
Exclusion criteria
Exclusion criteria: 1. Patients with upper limb cellulitis, ulcers, or peripheral vascular disease 2. WFNS grade > 3 3. Inadequate trans temporal window for TCD 4. Coiling or conservative management of aneurysm 5. Unruptured aneurysm
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of delayed cerebral ischemiaTimepoint: CT Perfusion scan will be performed at baseline before the first remote ischemic preconditioning (RIPC) session, at any neurological deterioration, and on day 7 of ictus/at discharge whichever is earlier. | — |
Secondary
| Measure | Time frame |
|---|---|
| Biomarkers of cardiac and neuronal injuryTimepoint: Data regarding serum biomarkers of neuronal injury (NO, GFAP, UCHL1) will be collected before the first session of RIPC, at 6-12hours after the first RIPC, on neurological deterioration and day 7 of ictus or day of discharge (whichever is earlier). Data regarding cardiac biomarkers (Troponin I, BNP, CKMB) will be collected before the first session of RIPC, 6-12 hours after the first RIPC, in the event of any myocardial dysfunction, and day 7 of ictus or day of discharge (whichever is earlier);Cardiac and neurological outcomeTimepoint: Myocardial stauts and hemodynamic stability during the hospital stay. The neurological status will be assessed using the Glasgow coma scale (GCS) every 24 hours during the period of stay in the hospital and GOSE (Glasgow outcome scale-extended) score at discharge.;Incidence of Cerebral vasospasm Timepoint: Transcranial Doppler (TCD) assessment will be done every 24 hours until 7 days post ictus or until discharge, whichever is earlier. The mean cerebral blood flow velocities (MCBFV) of the ipsilateral pathological vessel & the middle cerebral arteries will be recorded. | — |
Countries
India
Contacts
Public ContactSangeetha RP
National Institute of Mental Health and Neurosciences
Outcome results
None listed