Health Condition 1: B977- Papillomavirus as the cause of diseases classified elsewhere
Conditions
Interventions
Intervention1: Nil: Nil
Sponsors
ICMR National Institute for Research in Reproductive and Child health
Eligibility
Inclusion criteria
Inclusion criteria: • Sexually active women of age (30-50) years • Provide informed consent
Exclusion criteria
Exclusion criteria: 1. History of cervical cancer 2. Have had a total hysterectomy 3. Are pregnant or have been pregnant in the last month 4. History of diabetes, innate or acquired immunodeficiency, concomitant neoplastic diseases • Chronic inflammatory diseases/infections including aerobic vaginitis and other sexually transmitted diseases, • Corticosteroid or immune therapy • vagina douching within last 2 days • vaginal intercourse within last 3 days • systemic application of antifungal agents or antibiotics or pessaries within last 14 days of sampling
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| •Knowing the composition cervicovaginal virome including bacteriophages in healthy HPV negative women •Documentation of possible association of cervicovaginal microbiome and cytokine profiles with transient and persistent HPV infectionTimepoint: 0, 6 and 12 months | — |
Secondary
| Measure | Time frame |
|---|---|
| • Identification of microbial fingerprints that might be potentially utilized as biomarker for HPV persistence • The data generated may serve as an useful information for modification of vaginal microbiome to reduce progression of HPV infection Timepoint: longterm | — |
Countries
India
Contacts
Public ContactDr Kiran Munne
ICMR National Institute for Research in reproductive and child health
Outcome results
None listed