Effect of oral midodrine in preventing spinal anesthesia induced hypotension in patients undergoing lower abdominal surgery

Effect of oral midodrine in preventing spinal anesthesia induced hypotension in patients undergoing lower abdominal surgery - A Randomized Controlled Trial - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/10/059288

Enrollment

190

Registered

2023-10-30

Start date

Unknown

Completion date

Unknown

Last updated

2023-11-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: 3- Administration

Interventions

Intervention1: ORAL MIDODRINE: Midodrine hydrochloride, a prodrug for the active metabolite desglymidodrine. Desglymidodrine is an alpha-1 agonist that increases blood pressure and vascular tone via

Eligibility

Inclusion criteria

Inclusion criteria: Adult patients undergoing lower abdominal surgery under spinal anesthesia with ASA class 1 & 2.

Exclusion criteria

Exclusion criteria: Patients with known history of hypertension, on anti hypertensives. Patients with orthostatic hypotension or documented autonomic neuropathy. Patients with known cardiac diseases. Pregnant patients. Patients with benign prostatic hypertrophy. Patients with BMI >30 kg/m2 Patients with height of Patients with age >70 years.

Design outcomes

Primary

Measure	Time frame
incidence of hypotension (defined as SBP of 90 mmHg or reduction of SBP 20% from baseline)Timepoint: Throughout the duration of surgery.	—

Secondary

Measure	Time frame
? To compare the severity of hypotension between the groups ? To compare the number of episodes of hypotension between the groups ? To compare the total dose of Mephentermine between the groups ? To compare the volume of fluid bolus required to treat SAIH between the groups ? To compare the incidence of bradycardia & requirement of atropine between the groups ? To study any adverse events between the groupsTimepoint: Throughout the duration of surgery.	—

Measure

Time frame

? To compare the severity of hypotension between the groups ? To compare the number of episodes of hypotension between the groups ? To compare the total dose of Mephentermine between the groups ? To compare the volume of fluid bolus required to treat SAIH between the groups ? To compare the incidence of bradycardia & requirement of atropine between the groups ? To study any adverse events between the groupsTimepoint: Throughout the duration of surgery.

—

Countries

India

Contacts

Public ContactRANJITHA P

Jawaharlal institute of postgraduate medical education and research

mmc.senthil@gmail.com7598566983

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026