Health Condition 1: K729- Hepatic failure, unspecified
Conditions
Interventions
Intervention1: Donor-derived cell-free DNA combined with liver enzymes v/s liver enzymes alone: After live donor liver transplant, the patients will be randomized by simple randomization method into 2
Sponsors
Amrita institute of medical sciences and research
Eligibility
Inclusion criteria
Inclusion criteria: All Pts admitted to undergo live donor liver transplantation
Exclusion criteria
Exclusion criteria: 1.Multi-organ transplant recipients 2.Those who have undergone dual organ transplant from a single donor 3.Identical twin donor and recipient 4.Pregnant women 5.Patients with leukopenia, leukocytosis & inflammatory illness. 6.Patients who have undergone blood transfusions in the past one month. 7.Those who undergo regular & strenuous physical activity 8.Pts with symptoms of hematoma 9.Pts with middle hepatic venous thrombosis 10.Sepsis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Detection of allograft rejection with dd-cfDNA in combination with DSA in live donor liver transplant.Timepoint: 7 days, 1 month, 2 months & 4 months post-transplant | — |
Secondary
| Measure | Time frame |
|---|---|
| Integrity of liver graft measured with fibroscan, CTMRI or ultrasoundTimepoint: 2 years | — |
Countries
India
Contacts
Public ContactV U Lakshmi
Amrita Institute of Medical Sciences and Research
Outcome results
None listed