Comparative Evaluation of Modified Triple Antibiotic Loaded Injectable Scaffold versus Calcium Hydroxide in Managing Apical Periodontitis

Clinical Efficacy of Modified Triple Antibiotic Loaded Injectable Scaffold in Comparison to Calcium Hydroxide in the Treatment of Apical Periodontitis: A Randomised Clinical Trial - NIL

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/10/059223

Enrollment

Registered

2023-10-27

Start date

Unknown

Completion date

Unknown

Last updated

2023-11-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K041- Necrosis of pulp

Interventions

Intervention1: Modified triple antibiotic hydrogel as an intracanal medicament: The modified triple antibiotic based hydrogel will be used as the intracanal medicament after biomechanical preparation

Eligibility

Inclusion criteria

Inclusion criteria: Patients with non vital teeth and apical periodontitis Periapical index score of 1 to 4

Exclusion criteria

Exclusion criteria: Medically compromised individuals Individuals allergic to antibiotics Individuals with endo perio lesions Individuals with vital pulp Teeth with open apex

Design outcomes

Primary

Measure	Time frame
Microbial Load Reduction using PCRTimepoint: Baseline, 1 week	—

Secondary

Measure	Time frame
Post Operative Pain Measurement using Visual Analog ScaleTimepoint: Pre operative,8 hours, 24 hours, 48 hours, 7 days	—

Countries

India

Contacts

Public ContactJogikalmat Krithikadatta

Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University

krithikadatta.sdc@saveetha.com9840111369

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026