A clinical trial to study the effects of two drugs ketamine and etomidate on preserving heart function in patients with compromised heart function undergoing cardiac surgery

Effect of ketamine or etomidate on global longitudinal strain in patients with reduced left ventricular ejection fraction undergoing cardiac surgery: A randomized controlled trial - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/10/059017

Enrollment

Registered

2023-10-23

Start date

Unknown

Completion date

Unknown

Last updated

2023-11-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: KETAMINE: Ketamine dose 2 mg/kg will be administered through intravenous route during induction Control Intervention1: ETOMIDATE: Etomidate 0.2mg/kg will be administered through intrave

Eligibility

Inclusion criteria

Inclusion criteria: 1.Age 18-80 years 2.Patients with left ventricular ejection fraction

Exclusion criteria

Exclusion criteria: 1.Already Receiving Inotropes 2.Mechanical ventilation 3.Poor cardiac window 4.Patients not in sinus rhythm 5.Emergency surgeries 6.Re-do surgeries 7.Patients on pre-operative intra-aortic balloon pulsation (IABP) 8.Pregnancy

Design outcomes

Primary

Measure	Time frame
To study effect on Global longitudinal strainTimepoint: Transthoracic echocardiography will be done 5mins before and 10 minutes after giving study/control group drug	—

Secondary

Measure	Time frame
To compare the change in-1.Segmental myocardial function 2.Left ventricular outflow tract-velocity time integral (LVOT-VTI) derived cardiac output 3. Ejection fraction (EF) by Simpson’s method 4.Left ventriculoarterial coupling 4. To demonstrate correlation between wall motion index score & global longitudinal strain 5.For predicting post-operative inotropic requirements Timepoint: Transthoracic echocardiography will be done 5 minutes before & 10minutes after giving study/control group drug	—

Measure

Time frame

To compare the change in-1.Segmental myocardial function 2.Left ventricular outflow tract-velocity time integral (LVOT-VTI) derived cardiac output 3. Ejection fraction (EF) by Simpson’s method 4.Left ventriculoarterial coupling 4. To demonstrate correlation between wall motion index score & global longitudinal strain 5.For predicting post-operative inotropic requirements Timepoint: Transthoracic echocardiography will be done 5 minutes before & 10minutes after giving study/control group drug

—

Countries

India

Contacts

Public ContactDr.Manasa R

Jawaharlal Institute of Postgraduate Medical Education and Research

jipmersatyen@gmail.com9940973502

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026