Administration of low dose Ketamine and/or Dexmedetomidine for attenuation of post-operative pain following laparoscopic cholecystectomy

Intra-operative low dose Ketamine versus Dexmedetomidine for attenuation of acute post-operative pain following laparoscopic cholecystectomy: A randomized clinical trial - nil

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/10/059009

Enrollment

Registered

2023-10-23

Start date

Unknown

Completion date

Unknown

Last updated

2023-11-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Intra-operative low dose ketamine or dexmedetomidine or a combination of both: Study participants will be randomized into four groups. Group D will receive Inj Dexmedetomidine 0.25mcg/k

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients of either sex 2. Age group 18-60years 3. Patients of American Society of Anesthesiology (ASA) grade I and II 4. Undergoing elective laparoscopic Cholecystectomy

Exclusion criteria

Exclusion criteria: 1. Conversion to open cholecystectomy 2. Patients included in another study 3. Patients with history of significant cardiovascular disease (eg MI within the past 6months)

Design outcomes

Primary

Measure	Time frame
To compare the post-operative rescue analgesic requirements in the first 24hoursTimepoint: Outcome to be assessed at 24hours post-op	—

Secondary

Measure	Time frame
1. The Sedative effectsTimepoint: 30min post-op 1hour post-op 2hour post-op 6hour post-op 12hour post-op 24hour post-op;2. The time of first rescue analgesic requestTimepoint: When the VAS score more than or equal to 4;Other side effects like dizziness, nausea, vomitingTimepoint: Anytime within the first 24hours post-op	—

Countries

India

Contacts

Public ContactProf Laithangbam Pradipkumar Singh

Regional Institute of Medical Sciences, Imphal

drlaithangba@gmail.com7005238251

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026