Health Condition 1: F312- Bipolar disorder, current episodemanic severe with psychotic features
Conditions
Interventions
Intervention1: Allopurinol: Tablet Allopurinol 300 milligrams twice daily given orally for 4 weeks in Patients Of Bipolar Mania Along with a Single Mood stabilizer and An Antipsychotic.
Control Interv
Sponsors
Central Institute Of Psychiatry
Eligibility
Inclusion criteria
Inclusion criteria: 1. Male inpatients satisfying the ICD 10-DCR[1993] criteria of Bipolar affective disorder, current episode mania with psychotic symptoms with YMRS score of >20 and HAMD score 2. Age group of 18-50 years. 3. Drug naive or drug free patients for minimum 2 weeks for mood stabilizers/antipsychotics and 4 weeks for depot antipsychotics. 4. Those who give informed consent for participating in the study.
Exclusion criteria
Exclusion criteria: 1. Any other major co-morbid psychiatric diagnosis and substance dependence excluding nicotine & caffeine. 2. Significant current/ past medical or neurological illness including severe hepatic disease and history of severe head injury. 3. Patients taking antipurinergic drugs for other medical conditions. 4. Known hypersensitivity to Tab. Allopurinol or any of its components. 5. Patients who had received ECT in last 6 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Effectiveness Of Allopurinol (600MG/Day)as an Adjunctive Therapy as Assessed ON YMRS, BPRS, and ,OAS-M ,HAMDTimepoint: Baseline And 4 Weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| CHANGE IN SERUM URIC ACID LEVEL IN PATIENTS RECEIVING TAB ALLOPURINOL 600MG/DAYTimepoint: BASELINE AND 4 WEEKS | — |
Countries
India
Contacts
Public ContactDr Alok Pratap
CENTRAL INSTITUTE OF PSYCHIATRY
Outcome results
None listed