Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: NIL: NIL
Sponsors
K S Hegde Medical Academy
Eligibility
Inclusion criteria
Inclusion criteria: Adult patients belonging to American Society of Anaesthesiologist Physical Status (ASA PS) 1 and 2, undergoing elective surgeries under general anaesthesia
Exclusion criteria
Exclusion criteria: 1)Scheduled for emergency surgery 2)Hypersensitivity to the drug 3)History of QT prolongation, arrhythmias, recent myocardial infarction or heart failure 4)Patients with angle-closure glaucoma, urinary retention, seizures 5)Patients on monoamine oxidase inhibitors (MAOI) within last 14 days 6)Patients on drugs that can increase QT interval such as cisapride, pentamidine, procainamide, quinidine, sotalol, terfenadine 7)Renal and hepatic impairment 8)Pregnancy 9)Psychiatry patient and patient who are not able to understand instructions
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To evaluate preoperative anxiety with amitriptyline premedication To evaluate postoperative pain reduction with amitriptyline premedication in terms of a) Pain intensity b) Amount of postoperative opioid consumptionTimepoint: Anxiety measured using ALS prior to the pre-anaesthetic evaluation (ALS1), prior to the use of amitriptyline (ALS2) and 2 hour post amitriptyline use (ALS3). Post-operative HR, SBP, DBP, MAP, SpO2 will be noted every 15 min for the first hour and at 4th, 8th, 12th and 24th hour in postoperative period Pain score in postoperative period will be assessed using VAS at 4th, 8th, 12th, 24th hours. Total amount of opioid consumed will also be recorded postoperatively. | — |
Secondary
| Measure | Time frame |
|---|---|
| Evaluate the effect of amitriptyline premedication on a) Sedation b) Any other adverse effects Timepoint: Brussels sedation score will be assessed one hour after premedication and in the postoperative period.Any adverse effects such as arrhythmia, post-operative nausea and vomiting and dryness of mouth. | — |
Countries
India
Contacts
Public ContactDr Sumalatha R Shetty
K S Hegde Medical Academy
Outcome results
None listed