To compare the success rate of Stop GnRH agonist-antagonist protocol with conventional IVF protocols

To compare the efficacy of Stop GnRH agonist-antagonist protocol with conventional IVF stimulation protocols in terms of IVF outcomes: A randomized controlled trial

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/10/058780

Enrollment

120

Registered

2023-10-18

Start date

Unknown

Completion date

Unknown

Last updated

2024-09-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: N978- Female infertility of other origin

Interventions

Intervention1: Stop GnRH agonist-antagonist protocol: In Stop GnRH agonist-antagonist protocol,patients will receive GnRH agonist (Injection Leuprolide) 0.5mg/day subcutaneously from midluteal phase (

no dominant follicle & endometrial thickness 4mm on TVS). Gonadotrophin {Injection recombinant FSH (Gonal F) subcutaneously and/or Injection Human Menopausal Gonadotrophin/HMG intramuscularly} will b

Eligibility

Inclusion criteria

Inclusion criteria: 22 to 40 years of age Unexplained infertility Tubal factor Mild/moderate male factor infertility

Exclusion criteria

Exclusion criteria: • Polycystic ovary syndrome (PCOS) • Endometriosis • Fibroid or adenomyoma distorting the endometrial cavity • Severe male factor infertility • Previous two or more failed IVF/ICSI cycles • Patients who do not give written informed consent to participate

Design outcomes

Primary

Measure	Time frame
Number of oocytes retrieved Timepoint: 2 weeks	—

Secondary

Measure	Time frame
Cleavage rateTimepoint: 2 weeks;Clinical pregnancy rate per embryo transferTimepoint: 7 weeks;Cumulative clinical pregnancy rate Cumulative live birth rate (CLBR) Timepoint: 37 weeks;Cycle cancellation rateTimepoint: 2 weeks;Fertilization rateTimepoint: 2 weeks;Total dose of gonadotrophins required Duration of controlled ovarian stimulation Peak serum estradiol (E2) & progesterone (P4) on the day of trigger FORT/Follicular output rate Number of mature oocytes(MII) retrieved Timepoint: 2 weeks	—

Measure

Time frame

Cleavage rateTimepoint: 2 weeks;Clinical pregnancy rate per embryo transferTimepoint: 7 weeks;Cumulative clinical pregnancy rate Cumulative live birth rate (CLBR) Timepoint: 37 weeks;Cycle cancellation rateTimepoint: 2 weeks;Fertilization rateTimepoint: 2 weeks;Total dose of gonadotrophins required Duration of controlled ovarian stimulation Peak serum estradiol (E2) & progesterone (P4) on the day of trigger FORT/Follicular output rate Number of mature oocytes(MII) retrieved Timepoint: 2 weeks

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Countries

India

Contacts

Public ContactDr Aarthi K Jayraj

AIIMS, New Delhi

reetamahey52@gmail.com9818447845

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026