Health Condition 1: K740- Hepatic fibrosis
Conditions
Interventions
Sponsors
Institute of Liver and Biliary Sciences
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patients of Acute on chronic liver failure with septic shock (APASL, Sepsis -3 definitions) 2. Age 18-70yrs 3. Informed Consent
Exclusion criteria
Exclusion criteria: 1. Acute coronary syndrome, hemodynamically unstable arrhythmias 2. CKD stage 5 3. COPD with acute exacerbation 4. Acute CVA or Seizures 5. Extremely moribund patients 6. Hepato-cellular carcinoma (HCC), intrahepatic or extrahepatic malignancy 7. Pregnancy 8. Diabetic ketoacidosis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Survival in both groups.Timepoint: 7 days | — |
Secondary
| Measure | Time frame |
|---|---|
| days of ventilation, time taken for reversal of shock and 28day mortalityTimepoint: 28 days;Effect of etiology of ACLF on lactate kineticsTimepoint: Day3;Impact of delta arterial lactate and lactate clearance at 6h on clinical outcomes.Timepoint: 6 hours;Impact of oxygenation, respiratory acidosis, metabolic acidosis, anion gapTimepoint: 7 days;Lactate kinetics and lactate clearance at different time points.Timepoint: At 0, 6, 12,24,48 and 72 hours.;Study the impact of therapeutic interventions ( CRRT – impact of CRRT in a subgroup / Fluids/ Vasopressors) on lactate kinetics in ACLF patients with septic shockTimepoint: 7 days;Study the impact of type of infection (MDRO) on lactate kineticsTimepoint: 7 days;To develop a dynamic predictive model incorporating lactate kinetics to improve risk stratification and prediction of 28-day mortality.Timepoint: 28 days | — |
Countries
India
Contacts
Public ContactDr Rakhi Maiwall
Institute of Liver and Biliary Sciences
Outcome results
None listed