Health Condition 1: I228- Subsequent ST elevation (STEMI) myocardial infarction of other sites
Conditions
Interventions
Intervention1: Remote ischemic preconditioning: ? At the time of enrolment blood samples will be taken from the patients and divided into three
groups based on vitamin D levels (vitamin D levels =10
Lamidi et al., 2021
Mohammad Seyedsaadat et al., 2019
Zarbock et al., 2015)
? The blood samples will be taken before and after 24 hrs of PCI for evaluating cardiac injury
markers and inflammatory markers.
Control Intervention1: NIL: NIL
Sponsors
Department of Health Research
Eligibility
Inclusion criteria
Inclusion criteria: (1) All ACS patients with STEMI/NSTEMI enrolled for stent implantation (2) Age > 18 years. (3) Gender: Both M and F
Exclusion criteria
Exclusion criteria: (1) Patients below 18 years (2) Coronary artery bypass grafting (CABG) patients (3) Patients with permanent pacemaker (4) Patients with a Left Bundle Branch block on electrocardiogram (5) Patients with cardiogenic shock (6) Breastfeeding or pregnant women
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Difference in the levels of cardiac biomarkers, inflammatory markers (IL-6, IL-8, IL-10, IL-33, CRP, IFN gamma) and vitamin D before and 24 hours after PCI in control and RIPC arm.Timepoint: At the time of enrolment and 24 hours post PCI. | — |
Secondary
| Measure | Time frame |
|---|---|
| Comparison of the following outcomes between the RIPC & control arm: 1. Difference in survival at 30 days 2. Difference in non-fatal MACE at 30 day 3. Measurement of Ejection fraction, end diastolic volume, end systolic volume, WMSI, RWMA at 30 days following primary PCI Timepoint: 30 days after enrollment | — |
Countries
India
Contacts
Public ContactDr Harlokesh Narayan Yadav
All Institute of Medical Sciences New Delhi
Outcome results
None listed