COMPARE THE EFFECTIVENESS OF THREE PLATELET RICH PLASMA INJECTIONS GIVEN IN KNEE IN OSTEOARTHRITIS OF KNEE AT AN INTERVAL OF 4 DAYS VS 14 DAYS

COMPARE THE EFFICACY OF THREE PLATELET RICH PLASMA INJECTIONS IN OSTEOARTHRITIS OF KNEE: WITH AN INTERVAL OF 4 DAYS VS 14 DAYS: A RANDOMIZED CONTROL TRIAL. - Nil

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/10/058623

Enrollment

Registered

2023-10-13

Start date

Unknown

Completion date

Unknown

Last updated

2024-12-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M170- Bilateral primary osteoarthritis of knee Health Condition 2: M171- Unilateral primary osteoarthritisof knee

Interventions

Intervention1: 3 Platelet Rich Plasma injections: 3 Platelet Rich Plasma injections at an interval of 4 days each Control Intervention1: 3 Platelet Rich Plasma injections in knee: 3 Platelet Rich Plas

Eligibility

Inclusion criteria

Inclusion criteria: Patients with Grade 2 and Grade 3 Osteoarthritis Knee 1. Patients must be within 40 years to 75 years of age. 2. Should comply with the needs of study visits. 3. Patients without grade 4 osteoarthritis in the other knee who have mild to moderate osteoarthritis (OA) of the knee (Grade 2 or 3 on the KL grading scale). 4. Be capable of giving consent and willing to give consent, and comply with study-related needs, activities, and visits.

Exclusion criteria

Exclusion criteria: 1. Individuals with OA knees in grade 4 2. Patients who are either less than 40 years or more than 75 years 3. Patients who had an intra-articular injection of any medication in the past three months, such as corticosteroids or hyaluronic acid in the index knee. 4. Patients with any history of infection, trauma or surgery to the index knee . 5. Patients who have had organ transplantation, rheumatoid arthritis, another inflammatory condition, or who are already using immunosuppressive medications. 6. Female patients who intend to become pregnant, are nursing, or are currently pregnant. 7. Patients with severe psychiatric, psychological, and/or neurological abnormalities. 8. History of anticoagulant use 9. Known case of bleeding disorders

Design outcomes

Primary

Measure	Time frame
VAS Score at baseline v/s after 6 weeks, 3 months and after 6 months of procedureTimepoint: 1 YEAR	—

Secondary

Measure	Time frame
WOMAC Score, Knee Society Score (KSS), Sitting to standing time and walking distance at baseline v/s after 6 weeks, 3 months and after 6 months of procedureTimepoint: 1 YEAR	—

Countries

India

Contacts

Public ContactDr Abhijith K Jayan

AIIMS BHUBANESWAR

ortho_bishnu@aiimsbhubaneswar.edu.in9437182313

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026