Determining and comparing levels of neurogenic pain marker (Neurokinin A) and biomarker (MMP-8) in Pulp tissue and GCF of Primary healthy teeth nearing exfoliation and in reversible pulpitis.

Neurokinin A and MMP-8 levels in pulp tissue and GCF of primary healthy teeth nearing exfoliation and in reversible pulpitis teeth: An ELISA based study.

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/10/058615

Enrollment

Registered

2023-10-13

Start date

Unknown

Completion date

Unknown

Last updated

2023-10-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K040- Pulpitis

Interventions

Intervention1: Pulpotomy: A pulpotomy is a dental procedure that involves the removal of the infected portion of the pulp tissue in a tooth while preserving the healthy pulp tissue in the root canal.

Eligibility

Inclusion criteria

Inclusion criteria: 1 Children whose parents will consent to participate in the study. 2 Children of age 5-10 years old. 3 Teeth that are indicated for Pulpotomy. 4 Non-carious primary Mandibular Second Molar teeth, with 1/3rd or less than 1/3rd root length nearing exfoliation free from any pathology with Grade I or Grade II mobility, and root of the successor teeth has completed 2/3rd root formation.

Exclusion criteria

Exclusion criteria: 1 Children with an allergy to local anesthesia. 2 Children with systemic diseases, and intellectual disability. 3 Extensive plaque or calculus on the teeth and bleeding on probing present will not be included in this study.

Design outcomes

Primary

Measure	Time frame
Increased levels of NKA & MMP-8 will be expressed in pulp tissue & GCF in reversible pulpitis teeth specimens compared to primary non- carious teeth nearing exfoliation. Timepoint: first visit	—

Secondary

Measure	Time frame
NKA & MMP-8 levels will be considerably lower in GCF samples from teeth with reversible pulpitis 1 week after the pulpotomy procedure.Timepoint: 1 week	—

Countries

India

Contacts

Public ContactDr Aastha Jha

I.T.S. Centre for Dental Studies and Research, Muradnagar

dr.shivanimathur@its.edu.in8826221676

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026