Health Condition 1: F102- Alcohol dependence
Conditions
Interventions
Intervention1: Active gamma tACS: ACTIVE GAMMA tACS TO PATIENTS WILL BE GIVEN FOR 5 CONSECUTIVE DAYS IN A WEEK FOR TWO CONSECUTIVE WEEKS FOR 20 MIN.
Control Intervention1: Sham gamma tACS: SHAM GAMMA
Sponsors
Central Institute of Psychiatry
Eligibility
Inclusion criteria
Inclusion criteria: 1. Male patients diagnosed with Alcohol Dependence Syndrome as per International Classification of Disease - 11th revision - Diagnostic Criteria for Research (WHO, 2022). 2. Male with Alcohol Dependence aged between 18 to 60 years. 3. Severity of Alcohol Dependence Questionnaire (SADQ) in Male with Alcohol dependence greater than 16 4. The Clinical Institute Withdrawal Assessment for Alcohol (revised version) in Male with Alcohol dependence CIWA-Ar lesser than 10. 5. Right-handed 6. Male with Alcohol dependence who give informed consent. 7. Patients will be screened for cognitive deficit with Montreal Cognitive Assessment Test (MoCA). Cut off score is =25.
Exclusion criteria
Exclusion criteria: 1. Male with Alcohol dependence having any other co-morbid substance dependence except nicotine and caffeine. 2. Male with Alcohol dependence having any medical illness. 3. Male with Alcohol dependence having any other psychiatric illness, dementia, psychotic disorder, 4. Male with Alcohol dependence who are on any psychotropic medication or any anticraving medication in 2 weeks preceding and during the study. 5. Clinically diagnosed intellectual disability. 6. Past history of significant head injury. 7. Past history of epilepsy(Patients with history of alcohol withdrawal seizure will be included). 8. HAMD Score = 8.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Improvement of cognitive deficits in patients with Alcohol Use Disorder as response to Gamma-tACS.Timepoint: Improvement of cognitive deficits in patients with Alcohol Use Disorder as response to Gamma-tACS will be assessed at 0 week(Baseline) and 2 week | — |
Secondary
| Measure | Time frame |
|---|---|
| Improvement of craving in patients with Alcohol Use Disorder as response to Gamma-tACS.Timepoint: SYMPTOM SEVERITY WILL BE ASSESSED AT BASELINE WITH ACQ-SF-R, CGI-I before giving gamma tACs andPOST GAMMA tACS ASSESSMENT FOR SYMPTOM WITH ACQ-SF-R, CGI-I WILL BE REPEATED AT THE END OF 10 SESSIONS OF GAMM tACS. | — |
Countries
India
Contacts
Public ContactDr Alok Pratap
Central Institute of Psychiatry
Outcome results
None listed