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A clinical trial to study the effects of two drugs, Sugammadex and neostigmine in patients undergoing middle ear surgery for postoperative nausea and vomiting

Impact of sugammadex and neostigmine on post operative nausea and vomiting in middle ear surgery- A comparative study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2023/10/058570
Enrollment
140
Registered
2023-10-12
Start date
Unknown
Completion date
Unknown
Last updated
2024-11-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: H958- Other intraoperative and postprocedural complications and disorders of the ear and mastoid process, not elsewhere classified

Interventions

Intervention1: sugammadex 2mg/kg intravenous: post operative nausea and vomiting in middle ear surgery Control Intervention1: neostigmine 0.05mg/kg intravenous: post operative nausea and vomiting in m

Sponsors

Maharani laxmi bai medical college
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients providing Written informed consent ASA 1 and 2 patients Age between 18 to 45 years AND with Normal coagulation profile Schedule to undergo elective middle ear surgery

Exclusion criteria

Exclusion criteria: Not giving written informed consent ASA status 3 and 4 Abnormal coagulation profile Hemodynamically unstable patients With Hematological and Cardiovascular disorder psychiatric and neurological disorders With history of drug and alcohol abuse Body mass index more than 30 kg per meter square Allergy or contraindication to any study drugs

Design outcomes

Primary

MeasureTime frame
Comparing the Incidence and severity of PONV between the two study groups Timepoint: 24hour

Secondary

MeasureTime frame
The need for rescue antiemetics were evaluated for 24 h after surgical procedure between the groups. Compare the timing of first oral intake in both the study groups. Timepoint: 24hour

Countries

India

Contacts

Public ContactDr Chavi sethi

MLB MEDICAL COLLEGE

chitranganagupta@gmail.com8126703863

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026