Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: Nebulised versus Intravenously administered dexmedetomidine: 1 mcg/kg dexmedetomidine diluted to total volume of 5ml with normal saline 30 mins prior to induction of general anaesthesia
Sponsors
MAHATMA GANDHI MEDICAL COLLEGE AND HOSPITAL
Eligibility
Inclusion criteria
Inclusion criteria: Elective surgeries under general anaesthesia Patients of either sex having age 18-55years Body weight 50 to 70 kgs American society of anaesthesiologists (ASA) physical status I – II Patient’s written and informed consent
Exclusion criteria
Exclusion criteria: Patient refusal for the anaesthetic technique. Patients having mouth opening Patient with severe renal, hepatic, respiratory and cardiac disease. Any bleeding disorder or patient on anticoagulants History of allergy to study drug Patient belonging to ASA CLASS III, IV & V Patients on any sedatives, antipsychotics, antidepressants, anxiolytics or anticonvulsants and betablockers. Patient with any nasal pathology like nasal ulcer, nasal polyp, nasal septum deviation. Patients with difficult airway like cervical spine instability, facial fractures, partially obstructing laryngeal lesions (e.g., papilloma), craniofacial abnormalities, and temporo mandibular joint ankylosis. Patient coming for emergency surgery Pregnant patients H/O Covid infection during last 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome of the study will be to compare intravenous dexmedetomidine with nebulised dexmedetomidine as premedication for attenuation of laryngoscopic and intubation response.Timepoint: Vitals will be recorded on starting the study drugs and after every 5 minutes interval till the endotracheal tube is inserted. Also, vitals will be recorded immediately after intubation, 1,3 and 5 minutes after intubation thereafter every 5 minutes up to 30 minutes after insertion of endotracheal tube than at extubation. | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary outcome of the study will be to study and compare the sedation score and to study and compare the complications encountered with the two routesTimepoint: Sedation score will be calculated at 20 mins after giving drug and any complications will be noted during whole procedure. | — |
Countries
India
Contacts
Public ContactRajkumar Saraswat
MAHATMA GANDHI MEDICAL COLLEGE AND HOSPITAL
Outcome results
None listed