To compare the Effect of giving a drug before giving anaesthesia with giving the same drug after anaesthesia for control of postoperative pain & quality of recovery in laparoscopic renal Surgeries and the drug will be dexamethasone

Effect of preemptive administration of dexamethasone on postoperative pain & quality of recovery in laparoscopic renal Surgeries: a double blinded randomised controlled trial - Nil

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/10/058459

Enrollment

Registered

2023-10-09

Start date

Unknown

Completion date

Unknown

Last updated

2023-10-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: N071- Hereditary nephropathy, not elsewhere classified with focal and segmental glomerular lesions Health Condition 2: N29- Other disorders of kidney and ureter in diseases classified elsewhere

Interventions

Intervention1: IV DEXAMETHASONE: Group C will be administered 100ml normal saline 1hour prior to surgery and 0.2mg/kg IV Dexamethasone diluted in 100ml normal saline will be administered post inducti

Eligibility

Inclusion criteria

Inclusion criteria: 1. ASA physical status of I -III 2.Age more than 18 years 3.Patients undergoing Elective/Robotic Laparoscopic Renal surgery

Exclusion criteria

Exclusion criteria: 1.Chronic analgesic/ opioid use 2.Patient unable to communicate or operate PCA pump 3.BMI >35 4.Diabetes mellitus 5.Patient refusal or no informed consent or both

Design outcomes

Primary

Measure	Time frame
Cumulative fentanyl consumption in the first 24 hours postoperatively as delivered by a PCA( Patient controlled analgesia) pumpTimepoint: first 24 hours of postoperative period	—

Secondary

Measure	Time frame
1. Total intraoperative fentanyl requirement. 2. Time to activation of IV Fentanyl PCA pump postoperatively 3. Numeric Rating Scale at rest & on movement 30mins, 1hour, 2 hours, 4 hours, 8 hours, 12 hours & 24 hours postoperatively 4. Incidence & severity of opioid-related adverse effects such as nausea and vomiting, respiratory depression, pruritis and sedation 5. Requirement and dose of rescue analgesia 6. Effect on postoperative CRP levels at 24 hours and 48 hours 7. Time to mobilisation to chair from T0(Time of arrival to PACU) 8. Time to first walk(10metrs) from T0(Time of arrival to PACU) 9.Subjective sleep quality on the night of surgery 10.Patient satisfaction score at 24hr and 48 hours 11.QoR-40 score at 24hr and 48 hours postoperatively 12.Length of hospital stay 13.Blood sugar levels at 8hr, 24hr, and 48 hours Timepoint: 1.during the surgery 2.after the surgery 3.30mins,1,2,4,8,12 & 24 hours after surgery 4. postoperatively 5.during surgery 6. 24 & 48 hours postoperatively 10.at 24and 48 hours postoperatively 11. at 24 and 48 hour postoperatively 13. at 8 ,24 and 48 hours from start of surgery	—

Measure

Time frame

1. Total intraoperative fentanyl requirement. 2. Time to activation of IV Fentanyl PCA pump postoperatively 3. Numeric Rating Scale at rest & on movement 30mins, 1hour, 2 hours, 4 hours, 8 hours, 12 hours & 24 hours postoperatively 4. Incidence & severity of opioid-related adverse effects such as nausea and vomiting, respiratory depression, pruritis and sedation 5. Requirement and dose of rescue analgesia 6. Effect on postoperative CRP levels at 24 hours and 48 hours 7. Time to mobilisation to chair from T0(Time of arrival to PACU) 8. Time to first walk(10metrs) from T0(Time of arrival to PACU) 9.Subjective sleep quality on the night of surgery 10.Patient satisfaction score at 24hr and 48 hours 11.QoR-40 score at 24hr and 48 hours postoperatively 12.Length of hospital stay 13.Blood sugar levels at 8hr, 24hr, and 48 hours Timepoint: 1.during the surgery 2.after the surgery 3.30mins,1,2,4,8,12 & 24 hours after surgery 4. postoperatively 5.during surgery 6. 24 & 48 hours postoperatively 10.at 24and 48 hours postoperatively 11. at 24 and 48 hour postoperatively 13. at 8 ,24 and 48 hours from start of surgery

—

Countries

India

Contacts

Public ContactPurandar Mahaling

AIIMS NEW DELHI

vimirewari@gmail.com9818304880

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026