A clinical trial to study the effect of two methods of anesthesia, total intravenous anesthesia and inhalational anesthesia on neuroinflammation

The Effect Of Total Intravenous Anesthesia And Inhalational Anesthesia On The Markers Of Neuronal And Systemic Inflammation In Patients Undergoing Resection Of Supratentorial Gliomas: A Prospective Randomized Controlled Trial ? - TINSI TRIAL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/10/058436

Enrollment

Registered

2023-10-09

Start date

Unknown

Completion date

Unknown

Last updated

2023-10-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Inhalational aneshtesia: Anesthesia will be induced with Thiopentone 5-7 mg/kg and maintained with sevoflurane 0.7-1.1minimum alveolar concentration (MAC) titrated to a BIS value of 40-

Eligibility

Inclusion criteria

Inclusion criteria: 1) Patient consent 2) ASA class I-II 3)Age 18-65 years, undergoing craniotomy for supratentorial glioma in the neurosurgery operation theatre 4)Preoperative Karnofsky Performance Scale of 70 or above

Exclusion criteria

Exclusion criteria: 1) ASA class III,IV, V 2) Severe or uncompensated cardiovascular, renal, hepatic or endocrine disease 3) Pregnancy, postpartum and lactating females 4) Drug allergy to Propofol 5) Refusal to consent by patient or next of kin • patients with an active inflammatory process such as infection or immunologic illness known to increase the baseline immunologic markers, • Emergency surgery • Revision craniotomy at the same site • Preoperative history of seizures. • h/o preoperative cognitive dysfunction

Design outcomes

Primary

Measure	Time frame
1.Changes in the blood level of neuron specific enolase measured before induction of anesthesia & at the end of surgery 2.Changes in the blood level of interleukin -6 measured before the induction of anesthesia & at the end of surgery Timepoint: Before induction of anesthesia & after extubation	—

Secondary

Measure	Time frame
Hemodynamic parameters- heart rate & invasive blood pressure, urine output, maximum allowable blood loss, estimated blood loss, & total fluid input. 1) Tumour type, size, location, grade of tumor, duration of surgery, duration of anaesthesia, days of ICU stay, and days of hospital stay. 2) POSTOPERATIVE PARAMETERS: - Glasgow Outcome Scale - CAM score - Montreal cognitive assessment - BCSI Timepoint: IN ICU & 3 months after discharge	—

Measure

Time frame

Hemodynamic parameters- heart rate & invasive blood pressure, urine output, maximum allowable blood loss, estimated blood loss, & total fluid input. 1) Tumour type, size, location, grade of tumor, duration of surgery, duration of anaesthesia, days of ICU stay, and days of hospital stay. 2) POSTOPERATIVE PARAMETERS: - Glasgow Outcome Scale - CAM score - Montreal cognitive assessment - BCSI Timepoint: IN ICU & 3 months after discharge

—

Countries

India

Contacts

Public ContactDr SREEJA R

Sree Chitra Thirunal Institute of Medical Sciences and Technology, Thiruvananthapuram

drajay@sctimst.ac.in7012581920

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026