Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: ORAL MELATONIN: Oral melatonin 3mg will be given 120 minutes before the elective surgery.
Intervention2: ORAL CLONIDINE: Oral clonidine 100mcg will be given 120 minutes before the elect
Sponsors
PONDICHERRY INSTITUTE OF MEDICAL SCIENCES
Eligibility
Inclusion criteria
Inclusion criteria: Age 18 – 60 years of either sex. American society of Anesthesiologist 1 and 2 patients. (ASA 1 – A normal healthy patient. ASA 2 – A patient with mild systemic disease).
Exclusion criteria
Exclusion criteria: 1.Patients undergoing emergency surgeries. 2.Pregnant women 3.Patients receiving anti-psychotic medications 4.Cardiac illness 5.Known allergy to study drug 6.Anticipated difficult intubation 7.Patients on beta- blockers 8.Intubation requiring more than two attempts or more than 45 seconds.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary objective is to compare the effects of oral melatonin and oral clonidine on hemodynamic responses to laryngoscopy and endotracheal intubation.Timepoint: The hemodynamic parameters of heart rate, systolic blood pressure, diastolic blood pressure, mean arterial pressure and rate pressure product will be measured and recorded at 0, 3, 5, 10 minutes after intubation. | — |
Secondary
| Measure | Time frame |
|---|---|
| Ramsay sedation scoreTimepoint: preoperatively and up to one hour post operatively. | — |
Countries
India
Contacts
Public ContactDR SIVAKUMAR
PONDICHERRY INSTITUTE OF MEDICAL SCIENCES
Outcome results
None listed