FindTrial
Sign In

A study comparing 2 drugs in reversal of general anaesthesia

A randomized, controlled, double blinded clinical study comparing neostigmine-glycopyrrolate and sugammadex in the reversal of rocuronium induced neuromuscular block in surgeries lasting 1 to 2 hours. - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2023/10/058419
Enrollment
70
Registered
2023-10-06
Start date
Unknown
Completion date
Unknown
Last updated
2023-10-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Comparison study: Comparing time of extubation after administering reversal agents Control Intervention1: Sugammadex: A newer cyclodextrin molecule designed to reverse neuromuscular blo

Sponsors

SIMS hospitals, Department of anaesthesiology and pain management
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: ASA Grade 1 and 2, all patients willing to participate in the study who are undergoing surgery lasting 1 to 2 hours requiring general anaesthesia

Exclusion criteria

Exclusion criteria: ASA grade 3 and 4, BMI > 30, deranged liver function, deranged renal function, anatomical malformations in airway, history of malignant hyperthermia, history of neuromuscular disorders, allergy to any general anaesthesia medications

Design outcomes

Primary

MeasureTime frame
To compare the time of reversal from rocuronium induced neuromuscular blockade between neostigmine- glycopyrrolate and sugammadexTimepoint: To compare the time of extubation from rocuronium induced neuromuscular blockade between neostigmine- glycopyrrolate and sugammadex after administration of each agent in that specific group of patients—

Secondary

MeasureTime frame
To compare haemodynamic changes safety & hypersensitivity reactions & need for rescue reversal between neostigmine- glycopyrrolate & sugammadexTimepoint: Heart rate & Blood pressure & oxygen saturation monitoring every minute during extubation & every 15 minutes for 2 hours post extubation—

Countries

India

Contacts

Public ContactDr S Hiranmayee

SIMS hospitals

anaes1879@yahoo.com9790930134

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026