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Use of Liver and Splenic Stiffness in Patients of Acute on Chronic Liver Failure.

Prognostic Significance of Acute Change in Liver and Splenic Stiffness in Patients of Acute on Chronic Liver Failure. - NIL

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2023/10/058417
Enrollment
200
Registered
2023-10-06
Start date
Unknown
Completion date
Unknown
Last updated
2023-11-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K769- Liver disease, unspecified

Interventions

Intervention1: No intervention: No intervention

Sponsors

Institute of Liver and Biliary Sciences
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients of ACLF as per APASL criteria between 18 to 70 years of age 2. Patient and attendants willing to give informed consent

Exclusion criteria

Exclusion criteria: 1. Age 70 years 2. Survival less than 7 days 3. Cirrhosis with prior decompensation 4. Grade 3 ascites 5. Hepatic encephalopathy grade III &IV 6. HCC/SOL >2cm in liver 7. Patient with congestive heart failure 8. Patient with extrahepatic cholestasis 9. Portal vein thrombosis 10. BMI >30 kg/m2 11. Prior variceal endotherapy or ongoing beta blocker treatment for varices 12. Pregnant and lactating women 13. Patient with cardiac pacemaker 14. Critically ill patients

Design outcomes

Primary

MeasureTime frame
Acute changes in liver and splenic stiffness on day 7 in patients of ACLF predicts liver transplant free survival at 3 months Timepoint: 3 months—

Secondary

MeasureTime frame
Acute changes in liver and splenic stiffness on day 14 in patients of ACLF predicts liver transplant free survival at 3 monthsTimepoint: 3 months;Association of baseline and change in liver and splenic stiffness with etiology of ACLFTimepoint: Day 14;Association of baseline and change in liver and splenic stiffness with pattern of organ failuresTimepoint: Day 14;Association of baseline liver and splenic stiffness with grade of esophageal varices in ACLF patientsTimepoint: 1-7 days;Association of baseline liver and splenic stiffness with severity of ACLF by AARC-ACLF score, CLIF-C-ACLF score, MELD-Na and CTP at presentationTimepoint: Day 1;Association of change in liver and splenic stiffness with change in AARC-ACLF score and CLIF-C-ACLF score.Timepoint: Day 14;Association of changes in level of biochemical inflammatory markers with change in liver and splenic stiffness.Timepoint: Day 14—

Countries

India

Contacts

Public ContactDr Chitranshu Vashishtha

Institute of Liver and Biliary Sciences

chitranshuv@gmail.com01146300000

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026