Health Condition 1: F209- Schizophrenia, unspecified
Conditions
Interventions
Intervention1: Theta Transcranial Alternating Current Stimulation (tACS), Active.: Theta frequency tACS will be administered using a standard equipment using stringent safety measures. Cerebellum will
Sponsors
Central Institute of Psychiatry
Eligibility
Inclusion criteria
Inclusion criteria: 1. Diagnosis of Schizophrenia using International Classification of Diseases-11th edition (ICD-11) (WHO, 2019). 2. Patients giving written informed consent. 3. Right-handed patients. 4. Illness duration of equal to or more than 2 years. 5. The Positive and Negative Syndrome Scale for Schizophrenia (PANSS) with negative symptoms score of more than 15. 6. Scale for Assessment of Negative Symptoms (SANS) score more than 20. 7. Calgary Depression Scale for Schizophrenia (CDSS) score less than 7.
Exclusion criteria
Exclusion criteria: 1. Presence of co-morbid neurological or other psychiatric disorder(s). 2. Patient with co-morbid substance dependence, except nicotine and caffeine. 3. Patients having any metallic implants in the body. 4. Subjects who have received ECT in past 1 month.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cerebellar theta tACS results in a change in the negative symptoms at the end of 10 sessions.Timepoint: Improvement in the scores of PANSS, SANS, CGI at the end of 10 sessions(2 weeks) & 6 weeks as compared to baseline. | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in the levels of GABA, Glutamate, Glutamine, NAA & NAAG in cerebellum using Proton MR Spectroscopy post theta tACS administration to cerebellum.Timepoint: Baseline, at the end of 10 theta tACS sessions(2 weeks). | — |
Countries
India
Contacts
Public ContactDr Umesh S
Central Institute of Psychiatry
Outcome results
None listed