Role of dexmedetomidine medicine for kidney functions during general anaesthesia

Effect of dexmedetomidine on plasma renin and arginine-vasopressin levels during propofol or sevoflurane based anaesthesia - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/10/058412

Enrollment

Registered

2023-10-06

Start date

Unknown

Completion date

Unknown

Last updated

2023-10-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Intravenous Propofol and Dexmedetomidine: Intravenous dexmedetomidine 0.5 µg.kg-1 in 10 mL NS over 10 minutes after that infusion 0.5 µg.kg-1.h-1 in 10 mL NS (10 mL.h-1). A bolus of IV

Eligibility

Inclusion criteria

Inclusion criteria: 1. Individuals of age group 18 - 60 years 2. Both gender 3. BMI = 35 kg.m-2 4. American Society of Anesthesiologists (ASA) I and II 5. Patients undergoing elective major abdominal and intraperitoneal surgeries including laparotomy, hysterectomy, hemicolectomy.

Exclusion criteria

Exclusion criteria: 1. Patient’s unwillingness to participate in the study 2. Patients suffering from serious cardio-respiratory, neurological, hepatic or renal insufficiency 3. Patients with malignancies 4. Patients on centrally acting medications 5. Pregnancy and lactation 6. Patient allergic to the study drug 7. Alcohol and substance abuse

Design outcomes

Primary

Measure	Time frame
Plasma reninTimepoint: Before induction, 30 min into GA, 1 h after surgery in PACU and in the ward after 24 h	—

Secondary

Measure	Time frame
1. Blood parameters: Plasma AVP, plasma sodium and potassium concentration, plasma osmolality, plasma and serum creatinine 2. Urine parameters: Urine output, fractional excretion of sodium, fractional excretion of potassium, urinary sodium excretion, urinary potassium excretion, creatinine clearance 3. Maintenance dose of propofol per hour or sevoflurane per hour during surgery 4. Haemodynamics 5. Input-output of fluids 6. Length of stay in post-anaesthesia care unit (PACU) till modified Aldrete’s score =9 7. Any adverse eventsTimepoint: 1. Before induction, 30 min into GA, 1 h after surgery in PACU and in the ward after 24 h 2. Before induction, 30 min into GA, 1 h after surgery in PACU and in the ward after 24 h 3. Hourly during surgery 4. Perioperatively and up to 24 h postoperatively 5. Up to 24 h postoperatively 6. Postoperatively till patient gets shifted to ward 7. Up to 24 h postoperatively	—

Measure

Time frame

1. Blood parameters: Plasma AVP, plasma sodium and potassium concentration, plasma osmolality, plasma and serum creatinine 2. Urine parameters: Urine output, fractional excretion of sodium, fractional excretion of potassium, urinary sodium excretion, urinary potassium excretion, creatinine clearance 3. Maintenance dose of propofol per hour or sevoflurane per hour during surgery 4. Haemodynamics 5. Input-output of fluids 6. Length of stay in post-anaesthesia care unit (PACU) till modified Aldrete’s score =9 7. Any adverse eventsTimepoint: 1. Before induction, 30 min into GA, 1 h after surgery in PACU and in the ward after 24 h 2. Before induction, 30 min into GA, 1 h after surgery in PACU and in the ward after 24 h 3. Hourly during surgery 4. Perioperatively and up to 24 h postoperatively 5. Up to 24 h postoperatively 6. Postoperatively till patient gets shifted to ward 7. Up to 24 h postoperatively

—

Countries

India

Contacts

Public ContactSukanya Samanta

Government Medical College and Hospital, Chandigarh

vanitaanupam@yahoo.co.in9646121649

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026