Health Condition 1: N186- End stage renal disease
Conditions
Interventions
Intervention1: SYNBIOTICS: Intervention which include prescribing pro/pre-biotics and providing with dietary modifications(decreased protein intake and increased fiber intake) will be undertaken.
The
Sponsors
College of Pharmacy,SRIPMS
Eligibility
Inclusion criteria
Inclusion criteria: Patient undergoing hemodialysis and patient signing patient consent form.
Exclusion criteria
Exclusion criteria: Patient who have previously failed renal transplantation , who have ESRD of inflammatory cause(lupus, vasculitis, collagenopathies) , who had intake of probiotics,prebiotics in last 3 months, who have any medical condition affecting intestinal absorption(inflammatory bowel disease,short bowel syndrome, bariatric surgery) or severe dysmotility, who are taking any alternative medicine other than allopathic medicine, who are frail , who are treated with antibiotics , with severe malnutrition and with severe other diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change of uremic toxin from baseline to 6th week and 12th week. Measurement of serum concentrations of the uremic toxin indoxyl sulphate (mg/dL) by means of HPLC technique.Timepoint: Change of uremic toxin from baseline to 6th week and 12th week. Measurement of serum concentrations of the uremic toxin indoxyl sulphate (mg/dL) by means of HPLC technique. | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in gastrointestinal symptoms from baseline to 3rd and 6th month. Measurement of appetite and frequency and severity of gastrointestinal symptoms(nausea,vomiting,bloating,diarrhea,constipation)by means of GSRS questionnaire. Change in serum creatinine level and eGFR rate from baseline to 3rd and 6th monthTimepoint: baseline , 3rd ,6th month | — |
Countries
India
Contacts
Public ContactMs S Madhu mitha
College of pharmacy,SRIPMS
Outcome results
None listed