Health Condition 1: E65- Localized adiposity
Conditions
Interventions
Intervention1: Fecal Microbiota Transplantation (FMT): 100 g Fresh fecal sample taken from healthy donor added in 400 ml saline and filter its. Took 150 ml of for duodenoscopy of procedure
Control In
Sponsors
AIIMS
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patients with NAFLD liver biopsy-proven NASH 2. Written informed consent 3. Age between 18 and 60 years 4. Non-Cirrohtic 5. Any BMI
Exclusion criteria
Exclusion criteria: Exclusion Criteria 1. Patients on drugs are known to be associated with fatty liver 2. Antituberculosis drugs 3. Alcohol consumption ( >21 standard drinks per week in men and >14 standard drinks per week in women)(1) 4. Pregnant women 5. Other etiology of chronic liver diseases such as hepatitis C, Wilsonâ??s disease, autoimmune liver disease, alpha-1-antitrypsin deficiency, or Hemochromatosis. 6. Diabetes 7. Recent antibiotic use within the last 1 month 8. Probiotic intake, any gastric surgery
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| In the first step of the study, patients with NASH and no-NASH will be compared to understand the differences in the gut microbiome composition in the 2 groups ( 50 Patients of each group) through one YearsTimepoint: baseline and 1 year | — |
Secondary
| Measure | Time frame |
|---|---|
| The objective of fecal microbiota transplant (FMT) in lean & non-lean NAFLD is to restore a healthy gut microbiota & potentially improve the clinical outcomes of NAFLD.Timepoint: baseline & 1 year | — |
Countries
India
Contacts
Public ContactBipin Tiwari
AIIMS Delhi
Outcome results
None listed