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To study inflammatory response in low pressure laparoscopic cholecystectomy compared with standard pressure laparoscopic cholecystectomy

To compare inflammatory markers in low pressure pneumoperitoneum with deep neuromuscular block versus standard pressure pneumoperitoneum among patients undergoing laparoscopic cholecystectomy for gallstone disease: A Randomized Control Trial - NIL

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2023/10/058338
Enrollment
80
Registered
2023-10-05
Start date
Unknown
Completion date
Unknown
Last updated
2023-10-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K802- Calculus of gallbladder without cholecystitis

Interventions

Intervention1: Low pressure pneumoperitoneum with Deep neuromuscular block: In Patients undergoing Laparoscopic Cholecystectomy under Low pressure(8-10 mmHg) pneumoperitoneum with Deep neuromuscular b

Sponsors

Yashwant Singh Rathore
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.All patients undergoing laparoscopic cholecystectomy. 2.BMI=30 3.ASA grade 1 and 2 4.18 to 65 years of age both male and female. 5.Patient is able to follow instructions. 6.Able to provide informed written consent

Exclusion criteria

Exclusion criteria: 1.Age >65 or 2.BMI > 30 3.Any prior inflammatory conditions like Arthritides,chronic skin disease,IBD 4.Unable to give consent or patient refusal 5.Unfit for general anesthesia 6.Pregnancy

Design outcomes

Primary

MeasureTime frame
Inflammtory markers ( SERUM CRP,ESR, WBC COUNT,PLATELETCOUNT,serum CORTISOL,serum ALBUMIN, IL-1,IL-6,IL-17,TNF) levels at base line and 24 hours postoperatively and difference between them and compare between both groups (intervention and comparator)Timepoint: At base line and 24 hours postoperatively—

Secondary

MeasureTime frame
Difference in surgery time among 2 groups pain scores using numerical rating scale Difference assesed by calculating average between groupsTimepoint: 24 hours postoperatively—

Countries

India

Contacts

Public ContactDr Yashwant Singh Rathore

AIIMS New Delhi

dryashvant.r@gmail.com9911337726

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026