To compare effects of Propofol and Ketofol on Heart rate, Blood pressure, Mean Arterial pressure, SpO2 and Rate pressure product in Patients Undergoing Laparoscopic Cholecystectomy Under General Anaesthesia

Comparing Effect of Propofol V/S Ketofol As Induction Agents On Haemodynamic Variable In Patients Undergoing Laparoscopic Cholecystectomy Under General Anaesthesia Requiring Endotracheal Intubation : A Hospital Based Interventional Study at SMS Medical College, Jaipur - nil

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/10/058294

Enrollment

Registered

2023-10-05

Start date

Unknown

Completion date

Unknown

Last updated

2023-10-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Ketofol 1 mg/kg propofol plus 1 mg/kg ketamine (10 mg/ml diluion) diluted to 20 ml in a syringe.: duration around 15 min Control Intervention1: Propofol 2 mg/kg propofol diluted to 20 m

Eligibility

Inclusion criteria

Inclusion criteria: 1.Patients willing to give written informed consent. 2.Patients undergoing Laparoscopic surgery under General Anaesthesia. 3.ASA Grade I & II. 4. Age Groups-18-55 years.

Exclusion criteria

Exclusion criteria: 1.Patients with history of drug allergy, egg allergy. 2.Patients with uncontrolled hypertension and diabetes mellitus. 3.Patients with history of psychiatric illness. 4.Pregnant patients 5.Patients with BMI >30kg/m2

Design outcomes

Primary

Measure	Time frame
1.Mean Heart Rate , 2.Mean Systolic Blood Pressure, 3.Mean Diastolic Blood Pressure, 4.Mean Arterial Pressure, 5.Mean SpO2, 6.Mean Rate Pressure Product,Timepoint: Baseline After Induction of Anaesthesia Immediately after Intubation (T0) 1 min after Intubation (T1 ) 3 min after Intubation (T3) 5 min after Intubation (T5 ) 10 min after Intubation (T10) 15 min after Intubation (T15) Just before pneumoperitoneum created1.Mean Heart Rate , 2.Mean Systolic Blood Pressure, 3.Mean Diastolic Blood Pressure, 4.Mean Arterial Pressure, 5.Mean SpO2, 6.Mean Rate Pressure Product,	—

Measure

Time frame

1.Mean Heart Rate , 2.Mean Systolic Blood Pressure, 3.Mean Diastolic Blood Pressure, 4.Mean Arterial Pressure, 5.Mean SpO2, 6.Mean Rate Pressure Product,Timepoint: Baseline After Induction of Anaesthesia Immediately after Intubation (T0) 1 min after Intubation (T1 ) 3 min after Intubation (T3) 5 min after Intubation (T5 ) 10 min after Intubation (T10) 15 min after Intubation (T15) Just before pneumoperitoneum created1.Mean Heart Rate , 2.Mean Systolic Blood Pressure, 3.Mean Diastolic Blood Pressure, 4.Mean Arterial Pressure, 5.Mean SpO2, 6.Mean Rate Pressure Product,

—

Secondary

Measure	Time frame
Proportion of cases who will experience side effects.SHIVERING GRADE HYPOTENSION HYPERTENSION BRADYCARDIA TACHYCARDIA RESPIRATORY DEPRESSION PONV GRADE HALLUCINATION NYSTAGMUS DELIRIUMTimepoint: 15 MIN,30 MIN,45 MIN,60 MIN,75 MIN,90 MIN,105 MIN,120 MIN	—

Countries

India

Contacts

Public ContactAmanpreet Kaur

SMS Medical College , Jaipur

purohit.shobha@gmail.com7737050823

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026