Health Condition 1: M179- Osteoarthritis of knee, unspecified
Conditions
Interventions
Intervention1: Tranexamic Acid
: Injection Tranexamic Acid 20mg/kg in 100ml 0.9% Normal saline, single dose by intravenous route after the administration of spinal anesthesia, 15 minutes before tourni
Sponsors
Sriman Narayan M
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patients undergoing Unilateral Total Knee Replacement. 2. Both sexes. 3. Patients with Hemoglobin levels equal to more than 11g/dL. 4. Coagulation profile within normal limits.
Exclusion criteria
Exclusion criteria: 1. Patients undergoing simultaneous bilateral Total Knee Replacement Surgery. 2. Patient undergoing revision Knee Replacement surgeries. 3. Known patients of bleeding disorders. 4. Patients with known cases of Deep Vein Thrombosis, Pulmonary Embolism, and other vessel wall disorders. 5. Known cases of hematological disorders. 6. Known cases of renal insufficiency. 7. Patients with a Wells Score 2 or more. 8. Patients with a previous history of Cerebrovascular accidents, Transient Ischemic Attack, or Myocardial infarction. 9. Patient with a known history of seizure disorder. 10.Patients with known or suspected allergy to medication
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood loss, measured by drain output, drop in Hemoglobin, and Packed Cell Volume. Intraoperatively, by the number of swabs and gauze soaked, field loss, and irrigation aspirator volume.Timepoint: Blood loss, measured by drain output at 24 hours and 48 hours postoperatively, drop in Hemoglobin and Packed Cell Volume on postoperative day 1 and postoperative day 5. | — |
Secondary
| Measure | Time frame |
|---|---|
| Requirement of blood transfusionTimepoint: Intraoperatively during the time of surgery, on postoperative day 1, on postoperative day 5. | — |
Countries
India
Contacts
Public ContactSRIMAN NARAYAN M
Sri Ramachandra Institute of Higher Education and Research
Outcome results
None listed