Health Condition 1: N399- Disorder of urinary system, unspecified
Conditions
Interventions
Intervention1: NIL: NIL
Control Intervention1: NIL: NIL
Sponsors
Manipal Academy of Higher Education
DST INSPIRE
Eligibility
Inclusion criteria
Inclusion criteria: Control group: Infertile women attending the infertility clinic will be recruited for the study. Women with male factor infertility, normal BMI , regular menstrual cycles and no clinical signs of hyperandrogenism will be considered as control population. Obese group: Women with high BMI > 25kg/m2 and no clinical signs of hyperandrogenism will be considered under obese, non-PCOS group. PCOS group: Women with PCOS pattern (with metformin and without metformin treatment) will be included in the study. For PCOS group, women diagnosed with PCOS based on the Rotterdam criteria and undergo ovary stimulation will be selected. In addition, women with Type 2 diabetes will be included in this study group. PCOS + Metformin group: For PCOS with metformin group, women diagnosed with PCOS and Type 2 diabetes, undergoing metformin treatment for at least one month will be included.
Exclusion criteria
Exclusion criteria: Women with chronic cardiovascular disease, chronic kidney disease, diabetes, thyroid disease, and pulmonary disease will be excluded from the study. In addition, women using sex-steroids, women who had ovarian surgery in the past, women with premature ovarian failure and women who had chemotherapy in the past will be excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The study aims at understanding the complex pathophysiology of PCOS from the lens of altered iron metabolism/overload in the maternal body and also within the follicular fluid. This data is lacking in the Indian context and may provide vital clues to the pathophysiology treatment and management of PCOSTimepoint: 3 years | — |
Secondary
| Measure | Time frame |
|---|---|
| The association between the iron metabolism & ovarian function, its possible role as a causative factor for anovulation, poor oocyte function, poor embryo development & implantation process will be understood from this studyTimepoint: 3 years | — |
Countries
India
Contacts
Public ContactDr Sandhya Kumari M V
Kasturba Medical College
Outcome results
None listed