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Role of exercise in chronic liver disease patients undergoing liver transplantation.

Effect of supervised aerobic and resistance exercises on measures of frailty in CLD patients undergoing living donor liver transplantation- an open label RCT - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2023/10/058220
Enrollment
60
Registered
2023-10-03
Start date
Unknown
Completion date
Unknown
Last updated
2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K721- Chronic hepatic failure

Interventions

Intervention1: Supervised aerobic and resistance exercises and Standard medical therapy: Minimum 4 weeks of preoperative (living donor liver transplant) Supervised aerobic and resistance exercises St

Sponsors

Institute of Liver and Biliary Sciences
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Voluntary adult patient ( >18 years), decompensated chronic liver disease patients planned for LDLT, and Who pass the screening tests done in the OPD 1. Able to follow the introductory level exercises as per the protocol in the OPD without any adverse event. 2. No drop in the spO2 less than 93% on a 6 minute walk test.

Exclusion criteria

Exclusion criteria: 1. Patients with a physical disability (upper or lower limb deformity/ abnormality) 2. Exercise intolerance or inability to follow exercise regime. 3. Patients who fail the screening tests. 4. Patients on the following drugs- o Higher corticosteroid dose ( >0.1mg/kg/day), o BCAA (Branched chain amino acids) o Growth hormone, testosterone, SARMs, o Ghrelin agonists, myostatin antibodies, o Activin IIR antagonists, angiotensin converting enzyme inhibitors, o Espindolol (mixed beta agonist and antagonists), and o Fast skeletal muscle troponin activators.

Design outcomes

Primary

MeasureTime frame
Liver frailty index (Grip strength, Balance, Chair Stand test) Pulmonary function tests After 4 weeks of exercise- PFT Post operative time- PEF & FEV1. (Hand held machine) Physical performance- SPPB (Balance, Chair stands, Gait speed)Timepoint: After 4 weeks of intervention, on POD 14 & 30—

Secondary

MeasureTime frame
Time to extubation, need for re-intubation Duration of NIV support, Timepoint: During the course of hospital stay.;MortalityTimepoint: 90 Day;Myostatin levels in blood Skeletal muscle mass- L3SMITimepoint: Post intervention at 4 weeks & on POD14;Time to mobilization out of bed, Length of ICU stay, hospital stay Incidence of all septic complicationsTimepoint: During the course of hospital stay; Major surgical complications (CDC â?¥ grade 3) Pulmonary complications- Clinical evaluationTimepoint: During the course of hospital stay.—

Countries

India

Contacts

Public ContactViniyendra Pamecha

Institute of Liver and Biliary Sciences

viniyendra@yahoo.co.uk01146300000

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026