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Probiotic supplementation in improving symptom control among children with Asthma

Probiotic supplementation in improving symptom control among children with moderate to severe asthma: A double blind randomized trial - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2023/10/058216
Enrollment
60
Registered
2023-10-03
Start date
Unknown
Completion date
Unknown
Last updated
2025-10-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: J454- Moderate persistent asthma Health Condition 2: J459- Other and unspecified asthma Health Condition 3: J455- Severe persistent asthma

Interventions

Intervention1: prebiotic and probiotics: capsule containing Lactobacillus acidophilus 200 million, Lactobacillus rhamnosus 100 million, Lactobacillus casei 100 million, Lactobacillus plantarum 100 mil

Sponsors

DrNiranjan Biswal
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Children aged 6-18 years with moderate to severe asthma according to GINA criteria

Exclusion criteria

Exclusion criteria: Known cases of congenital or acquired immunodeficiency, cystic fibrosis and chronic pulmonary diseases, Alpha 1 antitrypsin deficiency, congenital heart disease, children with acute exacerbation, active respiratory infection.

Design outcomes

Primary

MeasureTime frame
To assess the effect of probiotic supplementation in symptom control among children with moderate to severe asthma using GINA asthma symptom control criteriaTimepoint: 0week 4weeks 8weeks 12weeks—

Secondary

MeasureTime frame
To assess the effect of probiotic supplementation in reducing the number & severity of acute exacerbations in children with moderate & severe asthma.Timepoint: 0week 4weeks 8weeks 12weeks;To assess the effect of Probiotic supplementation on Absolute Eosinophilic Count in children with moderate & severe asthma.Timepoint: 0week 12week;To assess the effect of Probiotic Supplementation on FEV1, FVC & FEV1/FVC in children with moderate and severe asthma.Timepoint: 0week 12week;To assess the effect of Probiotic supplementation on inflammatory markers IL-4, IL-5 & IL-13 in children with moderate and severe asthma .Timepoint: 0week 12week—

Countries

India

Contacts

Public ContactDr Monissh Palanisamy

JIPMER

drnbiswal@yahoo.com9442528402

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026