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To study the effect of xylocaine on intraocular pressure during intubation

A prospective placebo controlled study to evaluate the effect of intravenous 2% xylocaine on intraocular pressure (IOP) during endotracheal intubation in non ophthalmic surgeries - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2023/10/058197
Enrollment
100
Registered
2023-10-03
Start date
Unknown
Completion date
Unknown
Last updated
2023-10-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: 2% Xylocaine: 2% Xylocaine in dose of 2mg per kg BW (diluted upto 6 ml) injected intravenously ( duration of study around 20 minutes) Control Intervention1: Normal saline: 6ml normal sa

Sponsors

Department of anesthesiology and critical care
Lead Sponsor
Dr Parveen Kumar
Collaborator

Eligibility

Inclusion criteria

Inclusion criteria: 1.Belong to ASA class I and II 2.Weight ranging from 45-60 kg 3.Non-ophthalmic surgeries

Exclusion criteria

Exclusion criteria: 1. Anticipated difficult airway 2.history of hypertension 3. Treatment with beta blockers and calcium channel blockers or any other drug causing hemodynamic instability 4. Laryngoscopy time more than 30 seconds 5. Allergic to Xylocaine 5.pregnant and lactating mothers 6. Patients refusal to participate in study 7. Ophthalmic surgeries

Design outcomes

Primary

MeasureTime frame
To determine the changes on intraocular pressure (IOP) after giving 2% intravenous xylocaine.Timepoint: Intraocular pressure (IOP) will be measured by Perkins tonometer at pre induction baseline immediately after intubation & 1 3 5 & 15 minutes after that—

Secondary

MeasureTime frame
To determine the hemodynamic changes due to 2% intravenous xylocaine during endotracheal intubation.Timepoint: Heart rate today Systolic blood pressure, Diastolic blood pressure & Mean Blood Pressure ) will be measured by monitoring at pre induction (baseline), immediately after intubation and 1,3,5 and 15 minutes after that.—

Countries

India

Contacts

Public ContactDr Shubham Bhardwaj

Maharaja agrasen medical College agroha hisar

docsanjeevparmar77@gmail.com8059598861

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026