A clinical trial to study the effect of remote ischemic preconditioning on inflammatory markers in STEMI patients undergoing primary PCI

COMPARATIVE EVALUATION OF EFFECT OF REMOTE ISCHEMIC PRECONDITIONING ON INFLAMMATORY MARKERS IN STEMI PATIENTS UNDERGOING PRIMARY PCI AND ITS CORRELATION WITH SERUM VITAMIN D LEVELS - NIL

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/09/058123

Enrollment

120

Registered

2023-09-29

Start date

Unknown

Completion date

Unknown

Last updated

2023-10-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: I213- ST elevation (STEMI) myocardial infarction of unspecified site

Interventions

Intervention1: REMOTE ISCHEMIC PRECONDITIONING: Patients will be randomized to primary PCI alone or RIPC with primary PCI. RIPC will be done with an automated cuff placed on the right upper arm and in

Eligibility

Inclusion criteria

Inclusion criteria: 1) Patients with STEMI undergoing primary PCI 2) Age > 18 years 3) Window period less than 12 hours

Exclusion criteria

Exclusion criteria: 1) Patients below 18 years 2) History of Coronary artery bypass grafting (CABG) 3) Post CPR status 4) Previous MI 5) Those on allopurinol/ nicorandil 6) Patients with cardiogenic shock 7) Those who cannot give consent

Design outcomes

Primary

Measure	Time frame
Difference in the levels of inflammatory markers (IL-6, IL-8, IL-10, IL-33, CRP, IFN gamma) before and 24 hours after PCI in control and RIPC arm.Timepoint: At the time of enrolment and 24 hours post PCI.	—

Secondary

Measure	Time frame
Comparison of the following outcomes between the RIPC and control arm: 1. Difference in survival at 30 days 2. Difference in non-fatal MACE at 30 day Timepoint: 30 days after enrollment	—

Countries

India

Contacts

Public ContactDr D Chidanand

All India Institute of Medical Sciences New Delhi 110029

hnyadav@gmail.com8171544655

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026