Health Condition 1: F20- Schizophrenia
Conditions
Interventions
Intervention1: Clozapine: Administering clozapine and monitoring changes in QEEG.
Comparator none
Intervention2: T. Clozapine: not applicable
Intervention3: clozapine: The dose starts from 12.5mg, bui
Sponsors
Government medical college and hospital sector 32
Eligibility
Inclusion criteria
Inclusion criteria: 1. Diagnosis of schizophrenia according to ICD-11.24 2. Established as Treatment resistant schizophrenia as per Treatment response and resistance in psychosis (TRIPP) working group consensus guidelines3 3. Patients who have not received clozapine in the past.
Exclusion criteria
Exclusion criteria: 1. Patients with co-morbid substance dependence (except nicotine and caffeine) 2. Patients with history of severe cardiac or renal disorders, or a history of neutropenia, bone-marrow disorders, paralytic ileus, acute substance-induced psychosis or intoxication, circulatory collapse or epilepsy. 3. Patients on any depot I/M drug preparation. 4. Patients who have received ECT in past 2 weeks. 5. Patients who are lactating or pregnant. 6. Patient with any neurological disorders. 7. Patients with history of seizure in past. 8. Patients on any immunosuppressant. 9. Acutely suicidal patients. 10. Acutely violent patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Comparing QEEG between responders and non responders.Timepoint: Baseline, 3 weeks, 6 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| Assessing baseline QEEG of responders and non responders and comparing them.Timepoint: 0,6 weeks | — |
Countries
India
Contacts
Public ContactDr Shreya Batra
Government Medical College Hospital sector 32
Outcome results
None listed