To compare the usefulness of aescin and diclofenac sodium in managing pain, swelling, mouth opening after lower third molar surgery.

Comparison of the efficacy of aescin as against diclofenac sodium in the management of postoperative sequelae and their effect on salivary Prostaglandin E2 and serum C–reactive protein levels after surgical removal of impacted mandibular third molar: a randomized, double-blind, controlled clinical trial. - NIL

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/09/058004

Enrollment

Registered

2023-09-26

Start date

Unknown

Completion date

Unknown

Last updated

2023-10-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K011- Impacted teeth

Interventions

Intervention1: Aescin (escin): 120 mg/day to be taken orally in divided doses for 5 days after the surgical removal of impacted mandibular third molar Control Intervention1: Diclofenac sodium: 150 mg/

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients giving informed consent. 2. Age group 18-40 yrs. 3. ASA I and healthy ASAII physical status. 4. Patients presenting with impacted mandibular third molars. 5. Slightly or moderately difficult impacted mandibular third molars according to Pederson difficulty index.

Exclusion criteria

Exclusion criteria: 1. Presence of comorbid conditions. 2. Patients not reporting for follow-up as per study protocol. 3. Presence of systemic infections. 4. Presence of acute infection. 5. Known allergies to drugs under the study.

Design outcomes

Primary

Measure	Time frame
Prostaglandin E2 & serum C reactive protein levels measured by ELISATimepoint: Preoperatively 2nd postoperative day 5th postoperative day	—

Secondary

Measure	Time frame
Pain Swelling Mouth openingTimepoint: Preoperatively 2nd postoperative day 5th postoperative day	—

Countries

India

Contacts

Public ContactRajanikanth Kambala

Sharad Pawar Dental College and Hospital

rajanikanthmalaviya@gmail.com8888839380

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026