Study to find out Left ventricular muscle strain due to surgery, heart lung machine. This study analyses effects on longitudinal and circumferential strain in the Left ventricle muscle when given as continuous infusion vs. single shot dose of magnesium during end of cardiac bypass surgery.

Comparative randomised controlled trial of Left ventricular strain analysis between continuous infusion vs. bolus dose of magnesium sulphate on rewarming for patients undergoing CABG surgeries - Nil

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/09/057993

Enrollment

Registered

2023-09-25

Start date

Unknown

Completion date

Unknown

Last updated

2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: I251- Atherosclerotic heart disease of native coronary artery

Interventions

Intervention1: injection Magnesium sulphate: Injection Magnesium sulphate 50 mg/kg, given as continuous intravenous infusion given after inducing general anaesthesia in coronary bypass graft surgeries

Eligibility

Inclusion criteria

Inclusion criteria: 1)All Adult patients scheduled for elective CABG under CPB. 2)Age group between 18 â?? 70 years. 3)Normal sinus rhythm. 4)Patients with good left ventricle ejection fraction more than 50 %.

Exclusion criteria

Exclusion criteria: 1)Patients with other associated congenital heart anomalies. 2)Patients with valvular lesions with mitral stenosis, mitral regurgitation, Aortic stenosis, Aortic regurgitation defined ( All lesions defined as per 2020 ACC/AHA guidelines for valvular heart disease) 3)Contraindication to TEE probe placement like Oesophageal strictures, Oesophageal varices, oesophageal tumours, 4)Patients with Gastric ulcer, previous esophagectomy, oesophageal diverticulum, tracheoesophageal fistula, 5)Patients with previous oesophageal surgeries. 6)Patients with previous bariatric surgery, hiatus hernia, 7)Patients with large descending thoracic aortic aneurysm 8)Patients with Aortic disorders, pericardial diseases. 9)unilateral vocal cord paralysis, Oesophageal varices, post radiation therapy 10)Malignancies of any origin. 11)Patient refusing to participate in the project 12)Poor 2D & 3D image quality 13)patients abnormal airway issues 14)Emergency surgeries 15)Redo sternotomy surgeries.

Design outcomes

Primary

Measure	Time frame
1.To objectively analyse Global longitudinal strain (GLS), Peak segmental longitudinal strain (PSLS) in continuous infusion of magnesium group and bolus group. 2.To evaluate Global circumferential strain of left ventricle, in continuous infusion of magnesium group and bolus group. 3.To study the difference in vasoactive inotropic score, 4.To evaluate hemodynamics while coming off bypass to evaluate magnesium induced myocardial protection. 5. Duration of inotropic support, Mechanical ventilation required between both the groups. LVOT DIAMETER (cm) LVOT CROSS SECTIONAL AREA cm2 LVOT VTI cm LVOT STROKE VOLUME ml/beat LVOT CARDIAC OUTPUT (L/min) LVOT CARDIAC INDEX (L/min/m2) Timepoint: 1.Before institution of cardiopulmonary bypass 2.After termination of cardiopulmonary bypass	—

Measure

Time frame

1.To objectively analyse Global longitudinal strain (GLS), Peak segmental longitudinal strain (PSLS) in continuous infusion of magnesium group and bolus group. 2.To evaluate Global circumferential strain of left ventricle, in continuous infusion of magnesium group and bolus group. 3.To study the difference in vasoactive inotropic score, 4.To evaluate hemodynamics while coming off bypass to evaluate magnesium induced myocardial protection. 5. Duration of inotropic support, Mechanical ventilation required between both the groups. LVOT DIAMETER (cm) LVOT CROSS SECTIONAL AREA cm2 LVOT VTI cm LVOT STROKE VOLUME ml/beat LVOT CARDIAC OUTPUT (L/min) LVOT CARDIAC INDEX (L/min/m2) Timepoint: 1.Before institution of cardiopulmonary bypass 2.After termination of cardiopulmonary bypass

—

Secondary

Measure	Time frame
hemodynamics while coming off bypass Duration of inotropic support Mechanical ventilation required between both the groups. duration of icu stay Timepoint: vasoactive inotrope score every 6 hours postoperatively till 48 hours	—

Countries

India

Contacts

Public ContactDr K Sai Charan Sateesh

Sri Chitra tirunal institute of medical sciences and technology.

subin.ruchi@gmail.com8289983726

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Apr 4, 2026