To compare the heart rate and blood pressure changes during start of anaesthesia by giving two different drugs orally clonidine and tizanidine before the surgery

Comparative evaluation on effect of oral Tizanidine versus oral Clonidine on attenuation of haemodynamic response to laryngoscopy in patients undergoing spine surgery : A prospective randomized double blind study

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/09/057959

Enrollment

Registered

2023-09-22

Start date

Unknown

Completion date

Unknown

Last updated

2023-10-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: oral Tizanidine: tab. Tizanidine 4mg, orally single dose, one hour before the induction of anaesthesia with a sip of water. Patient will be followed intraoperatively and postopretively

Eligibility

Inclusion criteria

Inclusion criteria: Patients scheduled for spine surgery under general anaesthesia. Belonging to ASA (American Society of Anaesthesiology) class I, II

Exclusion criteria

Exclusion criteria: History of cardiovascular diseases e.g. Ischemic heart disease, conduction defects, etc. BMI 30 Uncontrolled hypertension and Diabetes Pregnant or lactating women. Drug allergy. Surgical complications (bleeding, dura puncture,nerve, vessel or organ injury) Surgery duration >3 hours. Patient’s baseline heart rate

Design outcomes

Primary

Measure	Time frame
To compare the the haemodynamic response to laryngoscopy and endotracheal intubation in two groups including heart rate(HR),systolic blood pressure(SBP),diastolic blood pressure(DBP),mean arterial pressure(MAP)Timepoint: values of Heart rate and blood pressure will be recorded preoperatively, and 1,3,5,7,10 min then every 10 min till 30 min after laryngoscopy.	—

Secondary

Measure	Time frame
Time of administration of first rescue analgesic.Timepoint: visual analouge score at 1,2,6,12,18,24 hours.;To compare post-operative Ramsay sedation score (RSS) in 2 groups Timepoint: Ramsay sedation score at 1,2,6,12,18,24 hours;To compare severity of pain in 2 groups using Visual analogue score(VAS) for 24 hoursTimepoint: visual analouge score at 1,2,6,12,18,24 hours.	—

Countries

India

Contacts

Public ContactDr Sakshi Thakore

Ananta Institute Of Medical Science And Research Centre

drsakshiarora88@gmail.com9571241824

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026