Health Condition 1: N179- Acute kidney failure, unspecified
Conditions
Interventions
Intervention1: Acute peritoneal dialysis: High volume peritoneal dialysis will be provided to those requiring kidney replacement therapy for acute kidney injury till the patient requires dialysis
Cont
Sponsors
Indian society of nephrology la renon research grant
Fluid research grant
Eligibility
Inclusion criteria
Inclusion criteria: 1. All patients over 18 years in the medical intensive care unit with acute kidney injury who require KRT as determined by treating physician and 2. Patients with hemodynamic compromise who are unfit to receive intermittent hemodialysis due to the same (systolic less than 100mm Hg or on any inotrope)
Exclusion criteria
Exclusion criteria: 1. Patients with peritonitis, active abdominal infections or any other abdominal pathology that is likely to interfere with intraperitoneal PD fluid dwells 2. Patients who have had previous major abdominal surgeries 3. Patients with abdominal or inguinal hernias 4. Patients with severe inflammatory bowel disease 5. Patients with severe coagulopathy (INR >2) and aPTT more than 1.5 times normal upper limit or platelets less than 50,000cells/cumm
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| a.To evaluate if there is significant difference in renal recovery or time to renal recovery at 30 days & 3 months in patients treated with SLED vs PD among patients who survive. (renal recovery is defined as either partial or complete: becoming dialysis independent, improvement in GFR by 25% or more) Timepoint: 30 days & 3 months | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. mortality difference between 2 groups 2. duration of hospitalization 3. metabolic & fluid control in the 2 groups 4. rate of complications 5. TIMP2 and IGFBP7 and renal recoveryTimepoint: 30 days & 3 months | — |
Countries
India
Contacts
Public ContactNisha Jose
Christian medical college and hospital
Outcome results
None listed