Health Condition 1: G319- Degenerative disease of nervous system, unspecified Health Condition 2: G318- Other specified degenerative diseases of nervous system
Conditions
Interventions
Intervention1: Intrathecal Technetium-99m Diethylenetriamine pentaacetate injection: We will inject five millicurie (volume of 0.5 ml) activity of Technetium-99m Diethylenetriamine pentaacetate (99mT
Sponsors
Jawaharlal Institute of Post-graduate Medical Education and Research (JIPMER)
Eligibility
Inclusion criteria
Inclusion criteria: Decompressive craniectomy group Adult (18 years or older) traumatic brain injury (TBI) patients who have undergone a decompressive craniectomy at least three months back. Decompressive craniectomy has to have the largest dimension of 12 cm or more on CT scan The brain under the craniectomy defect should not have gross damage, volume loss, or infarcts though some porencephalic changes due to previous head trauma are expected. Adults with Probable dementia Objective cognitive or behavioral impairment in at least two of the following Memory, Reasoning and handling complex tasks Visuospatial abilities, Language functions, Personality, behavior, or comportment A decline from the previous level of functioning Functional impairment Insidious onset and gradual progression Initial symptoms Amnestic Nonamnestic (language, executive) No other neurologic, psychiatric, or general medical disorders of severity that can interfere with cognition
Exclusion criteria
Exclusion criteria: Exclusion criteria for both groups: Abnormal creatinine levels for the age group. The creatinine clearance should be normal as the urinary excretion data will be affected if the kidney function is abnormal.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Find the pattern of SPECT-detected radiotracer distribution in patients with decompressive craniectomy and dementia. Timepoint: 24 hours after the injection | — |
Secondary
| Measure | Time frame |
|---|---|
| ee if the urinary excretion data vary significantly after cranioplasty in patients with craniectomy defects. Timepoint: Three months;Get the urinary excretion data in this group of patients Timepoint: 24 hours after the injection;Is there a difference in the lymph node uptake on the craniectomy side compared to that on the normal side? Timepoint: 24 hours after the injection;Is there demonstrable lymph node uptake after spinal subarachnoid injection of the radiotracer? Timepoint: 24 hours after the injection | — |
Countries
India
Contacts
Public ContactGopalakrishnan Madhavan Sasidharan
Jawaharlal Institute of Post-graduate Medical Education and Research (JIPMER)
Outcome results
None listed