Health Condition 1: E119- Type 2 diabetes mellitus without complications
Conditions
Interventions
Intervention1: Nil: Nil
Sponsors
Science and Engineering research Board (SERB) - Core Research Grant
Eligibility
Inclusion criteria
Inclusion criteria: Consenting adult participants that have a confirmed diagnosis of type 2 diabetes based on standard diagnostic criteria such as fasting plasma glucose level (case samples). Healthy consenting adult participants (control samples).
Exclusion criteria
Exclusion criteria: Participants having an active infection or who are taking immunosuppressive or antimicrobial medication during the time of sample collection or in the week prior to sample collection. Participants who are pregnant or have other conditions such as autoimmune diseases, neutropenia, or cancer will also be excluded to minimize potential confounding factors.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Outcome measures for measurement of neutrophil mediated responses to polymicrobial biofilms include neutrophil count, oxidative stress markers (such as measurement of ROS activity of neutrophils), neutrophil function (chemotaxis and phagocytosis assay) and levels of NET generation.Timepoint: Immediately after sample processing | — |
Secondary
| Measure | Time frame |
|---|---|
| Outcome measures for RNA sequencing experiments include gene expression analysisTimepoint: Immediately after RNA isolation | — |
Countries
India
Contacts
Public ContactDr T S Murali
Manipal School of Life Sciences, MAHE, Manipal
Outcome results
None listed