Comparison of two different doses of dexmedetomidine with ketamine -propofol combination in electroshock therapy

Comparison of effectiveness of two different dose of dexmedetomidine with ketamine-propofol combination for haemodynamic changes,seizure duration and recovery profile in patients undergoing modified electroconvulsive therapy: A randomised double-blind control study. - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/09/057792

Enrollment

111

Registered

2023-09-18

Start date

Unknown

Completion date

Unknown

Last updated

2023-10-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: F333- Major depressive disorder, recurrent, severe with psychotic symptoms Health Condition 2: O- Medical and Surgical Health Condition 3: F54- Psychological and behavioral factors associated with disorders or diseases classified elsewhere Health Condition 4: F203- Undifferentiated schizophrenia

Interventions

Intervention1: Different doses of dexmedetomidine with ketamine-propofol: Two different doses dexmedetomidine (0.5mcg/kg & 1mcg/kg ) in 100ml NS over 10 minutes with ketamine(0.5mg/kg)-propofol (0.5mg

Eligibility

Inclusion criteria

Inclusion criteria: ASA grade I and II having major depressive disorder (suicidal patients), schizophrenia, catatonia (in which first line treatment failed) were included who required MECT

Exclusion criteria

Exclusion criteria: • Patients with ASA PS III and above • Patients with history of allergy to study drugs • Pregnant females • Patients with respiratory, cardiovascular, hepatic, cerebrovascular and renal disease • Patients with intracranial hypertension, arterial aneurysm, cerebrovascular malformation etc. • Patients with glaucoma • Patients with history of seizure disorder • Patients with pacemaker

Design outcomes

Primary

Measure	Time frame
Haemodynamic changesTimepoint: Baseline(before study drug infusion),after study drug infusion,after induction,immediately after modified electroconvulsive therapy , then check 2 minute interval upto 10min , 5 minutes interval upto 30 min,15 minutes interval upto 60 mim.	—

Secondary

Measure	Time frame
1. Seizure duration 2. Recovery profile 3. Patient satisfaction score 4. Side effects / Complications, if any Timepoint: Upto 24 hours postoperatively	—

Countries

India

Contacts

Public ContactDr manoj Kumar Jain

R.N.T. Medical College, Udaipur

drsurendrasethi80@gmail.com9587150598

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026