Effect of platelet rich fibrin (derived from blood) on orthodontic treatment duration

EFFICACY OF PLATELET RICH FIBRIN (i-PRF) TO REDUCE ORTHODONTIC TREATMENT DURATION - A RANDOMIZED CONTROLLED TRIAL - NIL

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/09/057788

Enrollment

Registered

2023-09-18

Start date

Unknown

Completion date

Unknown

Last updated

2023-10-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K089- Disorder of teeth and supporting structures, unspecified Health Condition 2: K088- Other specified disorders of teethand supporting structures

Interventions

Intervention1: Injectable Platelet Rich Fibrin (i-PRF): Under strict aseptic conditions 10 mL of whole blood will be collected from the medial cubital vein into four vials not containing anticoagulant

Red blood cells at bottom part and yellowish liquid Platelet-rich Fibrin in the upper part. 2-3 mL liquid portion from the upper part will be drawn into disposable insulin syringe and the bottom part

Red blood cells at bottom part and yellowish liquid Platelet-rich Fibrin in the upper part. 2-3 mL liquid portion from the upper part wi

Eligibility

Inclusion criteria

Inclusion criteria: 1) Age range 15 to 30 years irrespective of gender 2) Class I / half cusp Class II malocclusion cases with moderate to severe crowding in maxillary arch ( >6mm calculated by Little’s Irregularity Index) 3) Overbite less than 50% 4) Full permanent dentition from second molar to second molar in both arches 5) Patients without significant medical history 6) Patients with healthy periodontium 7) Patients with positive informed consent

Exclusion criteria

Exclusion criteria: EXCLUSION CRITERIA 1) Unfavourable/distally tipped canine position 2) Platelet count less than normal 150000 per mcL of blood

Design outcomes

Primary

Measure	Time frame
Total treatment duration reduction percentageTimepoint: 1.5 year	—

Secondary

Measure	Time frame
Levelling and alignment improvement percentageTimepoint: 1.5 year	—

Countries

India

Contacts

Public ContactDr Sonar Kapil Mahendra

AIIMS, New Delhi

vilassamrit@live.in9899503560

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026