Comparison between efficacy of Clonidine and Dexmedetomidine with Levobupivacaine while being used in Spinal Anesthesia for lower limb surgery in Medical College Kolkata

A Comparative study of efficacy of intrathecal Clonidine and Dexmedetomidine with Levobupivacaine for lower limb surgery in Medical College Kolkata - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/09/057773

Enrollment

156

Registered

2023-09-18

Start date

Unknown

Completion date

Unknown

Last updated

2023-10-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical Health Condition 2: M218- Other specified acquired deformities of limbs

Interventions

Intervention1: Clonidine: 40 mcg Clonidine diluted to 0.5 ml Normal Saline will be taken with 2.5 ml of 0.5% Levobupivacaine and will be given intrathecally over 15 seconds Control Intervention1: Dexm

Eligibility

Inclusion criteria

Inclusion criteria: Patients scheduled for elective lower limb surgeries under spinal anesthesia during the period of data collection. Patients with physical status ASA-I and ASA-II. Patients with Mallampati score 1 and 2.

Exclusion criteria

Exclusion criteria: Patient refusal. Patients undergoing emergency surgery. Any known comorbidities. Patients with uncontrolled diabetes mellitus, heart disease, morbid obesity, vertebral deformity. Known allergy to drugs to be used in the study. Previous bleeding disorder or coagulopathy. Height 170 cm. Patients suffering from renal or hepatic derangements.

Design outcomes

Primary

Measure	Time frame
To compare the onset of sensory & motor block. To compare the duration of sensory and motor block. To compare the duration of post operative analgesia. Time to first rescue analgesia.Timepoint: Baseline, 4 weeks, 8 weeks	—

Secondary

Measure	Time frame
To compare the change in vitals of a patient between before & after injection of the above drugs. To measure the pulse rate via ECG, SPO2 via pulse oximetry. To compare the changes in blood pressure, pulse rate, product of mean blood pressure and pulse rate. To check for any adverse effects or abnormal response to the drugs.Timepoint: Baseline, 4 weeks, 8 weeks	—

Countries

India

Contacts

Public ContactDr Debankita Das

Medical College Kolkata

anjanagdastidar@gmail.com9831291666

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026